NVS-PAK1-C
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MedKoo CAT#: 462325

CAS#: 2250019-95-3

Description: NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 295 2 Weeks
10mg USD 730 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-26. Prices are subject to change without notice.

NVS-PAK1-C is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 462325
Name: NVS-PAK1-C
CAS#: 2250019-95-3
Chemical Formula: C23H25ClF3N5O
Exact Mass: 479.17
Molecular Weight: 479.9322
Elemental Analysis: C, 57.56; H, 5.25; Cl, 7.39; F, 11.88; N, 14.59; O, 3.33


Synonym: NVS-PAK1-C; NVS PAK1-C; NVS PAK1 C; NVS-PAK1 C

IUPAC/Chemical Name: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide

InChi Key: OINGHOPGNMYCAB-INIZCTEOSA-N

InChi Code: InChI=1S/C23H25ClF3N5O/c1-13(2)28-23(33)31-8-7-16(11-31)29-22-17-9-14(24)3-5-19(17)32(12-21(26)27)20-6-4-15(25)10-18(20)30-22/h3-6,9-10,13,16,21H,7-8,11-12H2,1-2H3,(H,28,33)(H,29,30)/t16-/m0/s1

SMILES Code: CC(C)NC(=O)N1CCC(C1)NC2=NC3=C(C=CC(=C3)F)N(C4=C2C=C(C=C4)Cl)CC(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Karpov AS, Amiri P, Bellamacina C, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015;6(7):776-781. Published 2015 May 22. doi:10.1021/acsmedchemlett.5b00102