UK-101

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MedKoo CAT#: 462258

CAS#: 1000313-40-5

Description: UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor. UK-101 induces cell apoptosis and can be used for the study of prostate cancer.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-31. Prices are subject to change without notice.

UK-101 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 462258
Name: UK-101
CAS#: 1000313-40-5
Chemical Formula: C25H48N2O5Si
Exact Mass: 484.3332
Molecular Weight: 484.753
Elemental Analysis: C, 61.94; H, 9.98; N, 5.78; O, 16.50; Si, 5.79


Synonym: UK-101; UK101; UK 101

IUPAC/Chemical Name: N-((S)-1-(((S)-1-((S)-2-(((tert-butyldimethylsilyl)oxy)methyl)oxiran-2-yl)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)heptanamide

InChi Key: OHYPIFPQEYUPDQ-RLSLOFABSA-N

InChi Code: InChI=1S/C25H48N2O5Si/c1-10-11-12-13-14-21(28)26-19(4)23(30)27-20(15-18(2)3)22(29)25(16-31-25)17-32-33(8,9)24(5,6)7/h18-20H,10-17H2,1-9H3,(H,26,28)(H,27,30)/t19-,20-,25-/m0/s1

SMILES Code: CCCCCCC(N[C@H](C(N[C@H](C([C@]1(CO1)CO[Si](C)(C(C)(C)C)C)=O)CC(C)C)=O)C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: de Bruin G, Huber EM, Xin BT, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014;57(14):6197-6209. doi:10.1021/jm500716s

2: Wehenkel M, Ban JO, Ho YK, Carmony KC, Hong JT, Kim KB. A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice. Br J Cancer. 2012;107(1):53-62. doi:10.1038/bjc.2012.243