WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462213
CAS#: unknown
Description: PSB 0474 is a potent and selective P2Y6 agonist.
MedKoo Cat#: 462213
Name: PSB 0474
CAS#: unknown
Chemical Formula: C17H18N2Na2O13P2
Exact Mass: 566.008
Molecular Weight: 566.2591
Elemental Analysis: C, 36.06; H, 3.20; N, 4.95; Na, 8.12; O, 36.73; P, 10.94
This product is not in stock, which may be available by custom synthesis.
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Synonym: PSB 0474
IUPAC/Chemical Name: 3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphate disodium salt
InChi Key: LEICCBKKYICWFH-BWBFMJMBSA-L
InChi Code: InChI=1S/C17H20N2O13P2.2Na/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(31-16)9-30-34(28,29)32-33(25,26)27;;/h1-7,12,14-16,22-23H,8-9H2,(H,28,29)(H2,25,26,27);;/q;2*+1/p-2/t12-,14-,15-,16-;;/m1../s1
SMILES Code: O[C@@H]([C@H]([C@H](N1C(N(CC(C2=CC=CC=C2)=O)C(C=C1)=O)=O)O3)O)[C@H]3COP([O-])(OP([O-])(O)=O)=O.[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 566.2591 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: El-Tayeb A, Qi A, Müller CE. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006;49(24):7076-7087. doi:10.1021/jm060848j
2: Mitchell C, Syed NI, Tengah A, Gurney AM, Kennedy C. Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. J Pharmacol Exp Ther. 2012;343(3):755-762. doi:10.1124/jpet.112.198051
