WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558991

CAS#: 13161-75-6

Description: Pteryxin is a coumarin that has been found in A.furcijuga and has diverse biological activities. It inhibits LPS-induced nitric oxide production in mouse peritoneal macrophages (IC50 = 20 µM). Pteryxin (100 µg/ml) completely inhibits collagen-induced aggregation of isolated rabbit platelets. It inhibits butyrylcholinesterase (BChE; IC50 = 12.96 µg/ml). Pteryxin reduces triacylglycerol levels and expression of the genes encoding sterol regulatory element binding protein 1c (SREBP-1c), fatty acid synthase (FASN), and acetyl-coenzyme A carboxylase 1 (ACC1) in 3T3-L1 adipocytes and HepG2 cells.

Chemical Structure

CAS# 13161-75-6

Theoretical Analysis

MedKoo Cat#: 558991
Name: Pteryxin
CAS#: 13161-75-6
Chemical Formula: C21H22O7
Exact Mass: 386.14
Molecular Weight: 386.400
Elemental Analysis: C, 65.28; H, 5.74; O, 28.98

Price and Availability

Size Price Availability Quantity
10mg USD 330 2 Weeks
25mg USD 540 2 Weeks
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IUPAC/Chemical Name: (2Z)-2-methyl-2-butenoic acid, (9R,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b′]dipyran-10-yl ester


InChi Code: InChI=1S/C21H22O7/c1-6-11(2)20(24)27-18-16-14(28-21(4,5)19(18)25-12(3)22)9-7-13-8-10-15(23)26-17(13)16/h6-10,18-19H,1-5H3/b11-6-/t18-,19-/m1/s1

SMILES Code: C/C=C(C)\C(O[C@@H]1C2=C3C(C=CC(O3)=O)=CC=C2OC(C)(C)[C@@H]1OC(C)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 386.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Matsuda, H., Murakami, T., Kageura, T., et al. Hepatoprotective and nitric oxide production inhibitory activities of coumarin and polyacetylene constituents from the roots of Angelica furcijuga. Bioorg. Med. Chem. Lett. 8(16), 2191-2196 (1998).

2. Chen, I.-S., Chang, C.-T., Sheen, W.-S., et al. Coumarins and antiplatelet aggregation constituents from formosan Peucedanum japonicum. Phytochemistry 41(2), 525-530 (1996).

3. Orhan, I.E., Senol, F.S., Shekfeh, S., et al. Pteryxin - A promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea. Food Chem. Toxicol. 109(Pt 2), 970-974 (2017).

4. Nugara, R.N., Inafuku, M., Takara, K., et al. Pteryxin: A coumarin in Peucedanum japonicum Thunb leaves exerts antiobesity activity through modulation of adipogenic gene network. Nutrition 30(10), 1177-1184 (2014).