WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574420

CAS#: 263849-50-9

Description: S-25585 is a neuropeptide Y (NPY) Y5 receptor antagonist that does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. It significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.

Chemical Structure

CAS# 263849-50-9

Theoretical Analysis

MedKoo Cat#: 574420
Name: S-25585
CAS#: 263849-50-9
Chemical Formula: C22H23F3N4O6S
Exact Mass: 528.129
Molecular Weight: 528.5
Elemental Analysis: C, 50.00; H, 4.39; F, 10.78; N, 10.60; O, 18.16; S, 6.07

Price and Availability

Size Price Availability Quantity
10.0mg USD 375.0 2 Weeks
50.0mg USD 1245.0 2 Weeks
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Synonym: S-25585, S25585, S 25585

IUPAC/Chemical Name: 1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazine


InChi Code: InChI=1S/C22H23F3N4O6S/c23-22(24,25)17-10-11-19(18(12-17)29(32)33)36(34,35)26-13-14-6-8-16(9-7-14)21(31)28-27-20(30)15-4-2-1-3-5-15/h1-5,10-12,14,16,26H,6-9,13H2,(H,27,30)(H,28,31)/t14-,16-

SMILES Code: O=C(NNC(C1=CC=CC=C1)=O)[C@H]2CC[C@H](CNS(=O)(C3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O)=O)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 528.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Beauverger et al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489 PMID: 15601626

2: Della-Zuana et al (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor. Int.J.Obes. 28 628

3: Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28 664


10.0mg / USD 375.0