WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574420
CAS#: 263849-50-9
Description: S-25585 is a neuropeptide Y (NPY) Y5 receptor antagonist that does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. It significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.
MedKoo Cat#: 574420
Name: S-25585
CAS#: 263849-50-9
Chemical Formula: C22H23F3N4O6S
Exact Mass: 528.129
Molecular Weight: 528.5
Elemental Analysis: C, 50.00; H, 4.39; F, 10.78; N, 10.60; O, 18.16; S, 6.07
Synonym: S-25585, S25585, S 25585
IUPAC/Chemical Name: 1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazine
InChi Key: BRMJFKLHWFZWOQ-KOMQPUFPSA-N
InChi Code: InChI=1S/C22H23F3N4O6S/c23-22(24,25)17-10-11-19(18(12-17)29(32)33)36(34,35)26-13-14-6-8-16(9-7-14)21(31)28-27-20(30)15-4-2-1-3-5-15/h1-5,10-12,14,16,26H,6-9,13H2,(H,27,30)(H,28,31)/t14-,16-
SMILES Code: O=C(NNC(C1=CC=CC=C1)=O)[C@H]2CC[C@H](CNS(=O)(C3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O)=O)CC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 528.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Beauverger et al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489 PMID: 15601626
2: Della-Zuana et al (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor. Int.J.Obes. 28 628
3: Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28 664
