S-24795
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574419

CAS#: 304679-75-2

Description: S-24795 is a partial agonist of α7 nAChR that has been shown to improve mnemonic function in aged mice for the treatment of aging-related memory disturbances. S-24795 displays more efficient memory-enhancing effects than memantine in Alzheimer's disease mouse models.


Chemical Structure

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S-24795
CAS# 304679-75-2

Theoretical Analysis

MedKoo Cat#: 574419
Name: S-24795
CAS#: 304679-75-2
Chemical Formula: C14H13BrINO
Exact Mass: 416.9225
Molecular Weight: 418.07
Elemental Analysis: C, 40.22; H, 3.13; Br, 19.11; I, 30.35; N, 3.35; O, 3.83

Price and Availability

Size Price Availability Quantity
10.0mg USD 290.0 2 Weeks
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Synonym: S-24795, S24795, S 24795

IUPAC/Chemical Name: 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide

InChi Key: LERUHBBUGAOYOD-UHFFFAOYSA-M

InChi Code: InChI=1S/C14H13BrNO.HI/c1-16-9-3-2-4-13(16)10-14(17)11-5-7-12(15)8-6-11;/h2-9H,10H2,1H3;1H/q+1;/p-1

SMILES Code: C[N+]1=CC=CC=C1CC(C2=CC=C(Br)C=C2)=O.[I-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 418.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lagostena et al (2008) The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 676 PMID: 18187166

2: Marighetto et al (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 197 499 PMID: 18265960

3: Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with Mem.. Psychopharmacology 196 555 PMID: 18034231

S-24795

10.0mg / USD 290.0