Nitroquine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 534914

CAS#: 22316-71-8

Description: Nitroquine is a bioactive chemical.

Chemical Structure

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Nitroquine
CAS# 22316-71-8
Instruction

Theoretical Analysis

MedKoo Cat#: 534914
Name: Nitroquine
CAS#: 22316-71-8
Chemical Formula: C15H12Cl2N6O
Exact Mass: 362.05
Molecular Weight: 363.202
Elemental Analysis: C, 49.60; H, 3.33; Cl, 19.52; N, 23.14; O, 4.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Nitroquine

IUPAC/Chemical Name: 2,4,6-Quinazolinetriamine, N(sup 6)-((3,4-dichlorophenyl)methyl)-N(sup 6)-nitroso- (9CI)

InChi Key: YVQXNYOBSUPZMH-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H12Cl2N6O/c16-11-3-1-8(5-12(11)17)7-23(22-24)9-2-4-13-10(6-9)14(18)21-15(19)20-13/h1-6H,7H2,(H4,18,19,20,21)

SMILES Code: NC1=NC(N)=C2C=C(N(CC3=CC=C(Cl)C(Cl)=C3)N=O)C=CC2=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 363.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang J, Huang FS, Xu WY, Song P, Duan JH, Yang S, Qiu ZW. Plasmodium yoelii: correlation of up-regulated prophenoloxidase and phenoloxidases with melanization induced by the antimalarial, nitroquine. Exp Parasitol. 2008 Mar;118(3):308-14. doi: 10.1016/j.exppara.2007.08.017. Epub 2007 Sep 14. PMID: 17936755.


2: Zhang J, Xu WY, Duan JH, Huang FS. [Correlation of Anopheles TEP1 gene with melanization induced by nitroquine]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2009 Aug;27(4):322-5. Chinese. PMID: 20066988.


3: Zhang J, Zhang S, Wang Y, Xu W, Zhang J, Jiang H, Huang F. Modulation of Anopheles stephensi gene expression by nitroquine, an antimalarial drug against Plasmodium yoelii infection in the mosquito. PLoS One. 2014 Feb 24;9(2):e89473. doi: 10.1371/journal.pone.0089473. PMID: 24586804; PMCID: PMC3933544.


4: Zhang J, Huang FS, Xu WY, Wang Y, Zhou TL, Duan JH. Plasmodium yoelii: correlation of TEP1 with mosquito melanization induced by nitroquine. Exp Parasitol. 2011 Jan;127(1):52-7. doi: 10.1016/j.exppara.2010.06.032. Epub 2010 Jul 1. PMID: 20599985.


5: Wang XX, Hu YM, Dong LJ, Deng BZ. [Studies on the mechanism of sporontocidal effect of nitroquine (CI-679) on P. gallinaceum (author's transl)]. Yao Xue Xue Bao. 1981 May;16(5):334-41. Chinese. PMID: 7195641.


6: Deng S, Hu Y. [Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1999;17(5):282-4. Chinese. PMID: 12563858.


7: Zhou SW, Hu YM. [Effect of nitroquine on protein synthesis of Plasmodium yoelii in vitro]. Zhongguo Yao Li Xue Bao. 1991 Jul;12(4):372-5. Chinese. PMID: 1807087.


8: Chen XH, Hu YM, Liao YQ, Ke JX, Zhang WJ. Effects of nitroquine on ultrastructures and cytochrome oxidase of exoerythrocytic Plasmodium yoelii in rat liver. Zhongguo Yao Li Xue Bao. 1998 Jul;19(4):390-3. PMID: 10375793.


9: Hu YM, Wang XX, Deng BZ, Liu FA, Zhu QP, Kuang MS. [Action of nitroquine on tissue schizonts of Plasmodium cynomolgi]. Zhongguo Yao Li Xue Bao. 1986 Jan;7(1):78-81. Chinese. PMID: 2945393.


10: Pang LH, Hu YM. [Effect of nitroquine (CL-679) in vitro on incorporation of [3H]hypoxanthine into DNA and RNA of Plasmodium yoelii]. Zhongguo Yao Li Xue Bao. 1988 Jul;9(4):349-52. Chinese. PMID: 2461638.


11: Yang S, Huang FS, Kuang MS, Duan JH, Zhang JR. [Assay of haemolymph protein concentration in Anopheles stephensi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2003;21(5):293-5. Chinese. PMID: 15108524.


12: Yang S, Huang FS. [Cloning, location and differential analysis of transcription factor Relish gene from Anopheles stephensi under different feeding conditions]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2005 Oct 30;23(5):257-61. Chinese. PMID: 16562473.


13: Feng CY, Hu YM, Liu Y, Kuang MS, Wang XX, Ren HX, Liu LZ, Yang Y, Deng BZ. [Effects of nitroquine on sporogenic cycle of Plasmodium cynomolgi]. Zhongguo Yao Li Xue Bao. 1982 Dec;3(4):273-6. Chinese. PMID: 6219546.


14: Chen XH, Hu YM. [Effects of four drugs on intraerythrocytic Plasmodium yoelii of early and late stages]. Zhongguo Yao Li Xue Bao. 1993 Nov;14 Suppl:S37-40. Chinese. PMID: 8010072.


15: Chen L, Dai ZR, Qian YL, Ma ZM, Guo FC, Liao ZH, Fu DD, Ma DQ, Pang XJ. [Observation on the efficacy of combined use of some new antimalarials for the treatment of falciparum malaria in Hainan Province]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1989;7(2):81-4. Chinese. PMID: 2680154.


16: Hu CR, Chen PH, Chen JM, Huang Q. [Electron microscopic observation of the sporogonic stage of Plasmodium gallinaceum after five antimalarials]. Zhongguo Yao Li Xue Bao. 1989 Sep;10(5):434-7. Chinese. PMID: 2618732.


17: Shao BR, Zhan CQ, Ha SH. [Evaluation of the phototoxicity of five antimalarial agents and praziquantel in mice]. Zhongguo Yao Li Xue Bao. 1986 May;7(3):273-5. Chinese. PMID: 2954378.


18: Dai ZR, Chen L, Li CJ, Qian YL. [Suppressive effect of 3 combinations of antimalarials against Plasmodium cynomolgi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1987;5(4):256-8. Chinese. PMID: 3450444.


19: Shi CM, Huang FS, Kuang MS, Duan JH. [Relationship between hemolymph phenol oxidase and melanization of oocysts of Plasmodium yoelii in Anopheles stephensi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000;18(1):11-3. Chinese. PMID: 12567462.


20: Schmidt LH, Rossan RN. Studies on the 2,4-diamino-6 substituted quinazolines. I. Antimalarial activities of 2,4-diamino-6-[(3,4-dichlorobenzyl)-nitrosoamino]-quinazoline (CI-679) as exhibited in rhesus monkeys infected with the Ro or Ro/PM strains of Plasmodium cynomolgi. Am J Trop Med Hyg. 1979 Sep;28(5):781-92. PMID: 114064.