WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574378

CAS#: 330829-30-6

Description: MRT-10 is a Smoothened (Smo) receptor antagonist that inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells and acts as an inverse agonist during nontranscriptional Hedgehog pathway activation.

Chemical Structure

CAS# 330829-30-6

Theoretical Analysis

MedKoo Cat#: 574378
Name: MRT-10
CAS#: 330829-30-6
Chemical Formula: C24H23N3O5S
Exact Mass: 465.1358
Molecular Weight: 465.52
Elemental Analysis: C, 61.92; H, 4.98; N, 9.03; O, 17.18; S, 6.89

Price and Availability

Size Price Availability Quantity
5.0mg USD 255.0 2 Weeks
10.0mg USD 415.0 2 Weeks
25.0mg USD 710.0 2 Weeks
50.0mg USD 1045.0 2 Weeks
100.0mg USD 1565.0 2 Weeks
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Synonym: MRT 10, MRT-10, MRT10

IUPAC/Chemical Name: N-((3-benzamidophenyl)carbamothioyl)-3,4,5-trimethoxybenzamide


InChi Code: InChI=1S/C24H23N3O5S/c1-30-19-12-16(13-20(31-2)21(19)32-3)23(29)27-24(33)26-18-11-7-10-17(14-18)25-22(28)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,25,28)(H2,26,27,29,33)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 465.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Solinas et al (2012) Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 55 1559 PMID: 22268551

2. Manetti et al (2010) Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol.Pharmacol. 78 658 PMID: 20664000


5.0mg / USD 255.0