MCL-0020

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574372

CAS#: 475498-26-1

Description: MCL-0020 is a selective melanocortin MC4 receptor antagonist that significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. MCL-0020 exhibits anxiolytic-like activity in vivo.


Chemical Structure

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MCL-0020
CAS# 475498-26-1

Theoretical Analysis

MedKoo Cat#: 574372
Name: MCL-0020
CAS#: 475498-26-1
Chemical Formula: C34H39N7O4
Exact Mass: 609.31
Molecular Weight: 609.731
Elemental Analysis: C, 66.98; H, 6.45; N, 16.08; O, 10.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MCL-0020, MCL 0020, MCL0020

IUPAC/Chemical Name: (S)-2-((R)-2-acetamido-3-(naphthalen-2-yl)propanamido)-N-((R)-1-amino-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide

InChi Key: FJFLYSMWSRRMRO-FRXPANAUSA-N

InChi Code: InChI=1S/C34H39N7O4/c1-21(42)39-30(20-23-13-15-25-8-3-5-10-27(25)18-23)33(45)40-28(11-6-16-38-34(36)37)32(44)41-29(31(35)43)19-22-12-14-24-7-2-4-9-26(24)17-22/h2-5,7-10,12-15,17-18,28-30H,6,11,16,19-20H2,1H3,(H2,35,43)(H,39,42)(H,40,45)(H,41,44)(H4,36,37,38)/t28-,29+,30+/m0/s1

SMILES Code: CC(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble to 2 mg/ml in 25% ethanol / water

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM.
In vitro activity: In addition, MCL0020 significantly attenuated the cAMP formation induced by alpha-MSH in COS-1 cells expressing the melanocortin MC4 receptor without affecting basal cAMP contents. Reference: Eur J Pharmacol. 2003 Aug 1;474(1):95-101. https://pubmed.ncbi.nlm.nih.gov/12909200/
In vivo activity: Restraint stress significantly reduced food intake in rats, and i.c.v. administration of MCL0020 dose-dependently and significantly attenuated restraint stress-induced anorexia without affecting food intake. Swim stress induced reduction in the time spent in the light area in the mouse light/dark exploration test, and MCL0020 significantly prevented it. Reference: Eur J Pharmacol. 2003 Aug 1;474(1):95-101. https://pubmed.ncbi.nlm.nih.gov/12909200/

Preparing Stock Solutions

The following data is based on the product molecular weight 609.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: Chaki S, Ogawa S, Toda Y, Funakoshi T, Okuyama S. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003 Aug 1;474(1):95-101. doi: 10.1016/s0014-2999(03)02033-8. PMID: 12909200.
In vitro protocol: Chaki S, Ogawa S, Toda Y, Funakoshi T, Okuyama S. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003 Aug 1;474(1):95-101. doi: 10.1016/s0014-2999(03)02033-8. PMID: 12909200.
In vivo protocol: Chaki S, Ogawa S, Toda Y, Funakoshi T, Okuyama S. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003 Aug 1;474(1):95-101. doi: 10.1016/s0014-2999(03)02033-8. PMID: 12909200.

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Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID: 12909200