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MedKoo CAT#: 207129

CAS#: 1422365-93-2 (free base)

Description: IM156 is an oxidative phosphorylation inhibitor. IM156 is an orally bioavailable biguanide compound and mitochondrial oxidative phosphorylation (OxPhos) inhibitor, with potential antineoplastic activity. Upon administration, IM156 inhibits oxidative phosphorylation, decreases mitochondrial function, prevents tumor cell metabolism and deprives tumor cells of energy, thereby preventing tumor cell proliferation.

Chemical Structure

CAS# 1422365-93-2 (free base)

Theoretical Analysis

MedKoo Cat#: 207129
Name: IM156
CAS#: 1422365-93-2 (free base)
Chemical Formula: C13H16F3N5O
Exact Mass: 315.1307
Molecular Weight: 315.3002
Elemental Analysis: C, 49.52; H, 5.12; F, 18.08; N, 22.21; O, 5.07

Price and Availability

Size Price Availability Quantity
50.0mg USD 250.0 Same day
100.0mg USD 450.0 Same day
200.0mg USD 750.0 Same day
500.0mg USD 1650.0 Same day
1.0g USD 2850.0 Same day
2.0g USD 4750.0 Same day
5.0g USD 6450.0 2 Weeks
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Related CAS #: 1422365-52-3 (HCl)   1422365-93-2 (free base)   1422365-94-3 (acetate)   2043654-64-2 (TFA)   2043654-70-0 (malonate)   2043654-72-2 (furmate)   2043654-97-1 (tosylate)   2043654-98-2 (mesylate)    

Synonym: IM156; IM-156; IM 156;

IUPAC/Chemical Name: N-[Imino[[4-(trifluoromethoxy)phenyl]amino]methyl]-1-pyrrolidinecarboximidamide


InChi Code: InChI=1S/C13H16F3N5O/c14-13(15,16)22-10-5-3-9(4-6-10)19-11(17)20-12(18)21-7-1-2-8-21/h3-6H,1-2,7-8H2,(H4,17,18,19,20)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 315.3002 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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10.0mg / Not available

Additional Information

Mitochondrial OxPhos is overactivated in cancer cells and plays a key role in tumor cell proliferation. Drug resistant tumor cells are very susceptible to decreased mitochondrial OxPhos as they cannot easily compensate for the decrease in mitochondrial function by increasing glycolysis