A-987306
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MedKoo CAT#: 574336

CAS#: 1082954-71-9

Description: A-987306 is a potent histamine H4 receptor antagonist that is selective for H3, H1 and H2 receptors. A-987306 blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo.


Chemical Structure

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A-987306
CAS# 1082954-71-9

Theoretical Analysis

MedKoo Cat#: 574336
Name: A-987306
CAS#: 1082954-71-9
Chemical Formula: C18H25N5O
Exact Mass: 327.2059
Molecular Weight: 327.43
Elemental Analysis: C, 66.03; H, 7.70; N, 21.39; O, 4.89

Price and Availability

Size Price Availability Quantity
10.0mg USD 435.0 2 Weeks
50.0mg USD 1475.0 2 Weeks
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Synonym: A 987306, A-987306, A987306

IUPAC/Chemical Name: (7aS,11aS)-4-(piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine

InChi Key: DJKJVWJQAVGLHJ-YPMHNXCESA-N

InChi Code: InChI=1S/C18H25N5O/c19-18-21-16-12(17(22-18)23-9-7-20-8-10-23)5-6-14-15(16)11-3-1-2-4-13(11)24-14/h11,13,20H,1-10H2,(H2,19,21,22)/t11-,13+/m1/s1

SMILES Code: NC3=NC1=C(C(N4CCNCC4)=N3)CCC2=C1[C@@](CCCC5)([H])[C@@]5([H])O2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 327.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Liu et al (2008) cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. J.Med.Chem. 51 7094 PMID: 18983139

Leurs et al (2009) Molecular and biochemical pharmacology of the histamine H4 receptor. Br.J.Pharmacol. 157 14 PMID: 19413568

A-987306

10.0mg / USD 435.0