Xenopsin
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MedKoo CAT#: 574325

CAS#: 51827-01-1

Description: Xenopsin is a neurotensin-like octapeptide that inhibits neurotensin binding to rat brain synaptic membranes and induces contraction of isolated guinea pig ileum in the presence of neostigmine. Xenopsin increases the firing rate of dopaminergic neurons and increases adrenal, pancreatic, and ileal blood flow and plasma levels of pancreatic polypeptide, glucagon, substance P, and cortisol, as well as reduces tetragastrin-induced gastric acid secretion.


Chemical Structure

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Xenopsin
CAS# 51827-01-1

Theoretical Analysis

MedKoo Cat#: 574325
Name: Xenopsin
CAS#: 51827-01-1
Chemical Formula: C47H73N13O10
Exact Mass: 979.5603
Molecular Weight: 980.18
Elemental Analysis: C, 57.59; H, 7.51; N, 18.58; O, 16.32

Price and Availability

Size Price Availability Quantity
1.0mg USD 230.0 2 Weeks
5.0mg USD 515.0 2 Weeks
10.0mg USD 795.0 2 Weeks
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Synonym: pGlu-Gly-Lys-Arg-Pro-Trp-Ile-Leu; Xenopsin

IUPAC/Chemical Name: ((S)-5-oxopyrrolidine-2-carbonyl)glycyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-L-leucine

InChi Key: VVZLRNZUCNGJQY-KITDWFFGSA-N

InChi Code: InChI=1S/C47H73N13O10/c1-5-27(4)39(44(67)58-35(46(69)70)22-26(2)3)59-42(65)34(23-28-24-52-30-13-7-6-12-29(28)30)57-43(66)36-16-11-21-60(36)45(68)33(15-10-20-51-47(49)50)56-41(64)31(14-8-9-19-48)55-38(62)25-53-40(63)32-17-18-37(61)54-32/h6-7,12-13,24,26-27,31-36,39,52H,5,8-11,14-23,25,48H2,1-4H3,(H,53,63)(H,54,61)(H,55,62)(H,56,64)(H,57,66)(H,58,67)(H,59,65)(H,69,70)(H4,49,50,51)/t27-,31-,32-,33-,34-,35-,36-,39-/m0/s1

SMILES Code: O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H]([C@H](CC)C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)[C@H]3N(C([C@@H](NC([C@@H](NC(CNC([C@@H](N4)CCC4=O)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 980.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Zinner, M.J., Kasher, F., Modlin, I.M., et al. Effect of xenopsin on blood flow, hormone release, and acid secretion. Am. J. Physiol. 243(3), G195-199 (1982).

2. Granier, C., van Rietschoten, J., Kitabgi, P., et al. Synthesis and characterization of neurotensin analogues for structure/activity relationship studies. Acetyl-neurotensin-(8--13) is the shortest analogue with full binding and pharmacological activities. Eur. J. Biochem. 124(1), 117-124 (1982).

3. Pozza, M.F., Küng, E., Bischoff, S., et al. The neurotensin analog xenopsin excites nigral dopamine neurons. Eur. J. Pharmacol. 145(3), 341-343 (1988).