WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462167
Description: YU253434 is a novel γ-lactam pyrazolidinone that has the potential to ttreat multidrug-resistant Gram-negative bacterial pathogens.
MedKoo Cat#: 462167
Chemical Formula: C27H26N8O12S
Exact Mass: 686.1391
Molecular Weight: 686.609
Elemental Analysis: Chemical Formula: C27H26N8O12S Exact Mass: 686.1391 Molecular Weight: 686.6090 Elemental Analysis: C, 47.23; H, 3.82; N, 16.32; O, 27.96; S, 4.67
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Related CAS #: 2408801-88-5
Synonym: YU253434; YU-253434; YU 253434;
IUPAC/Chemical Name: (S,Z)-6-(2-(2-aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-2-((2-(5,6-dihydroxy-1,3-dioxoisoindolin-2-yl)ethyl)carbamoyl)-5-oxo-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazole-3-carboxylic acid
InChi Key: NDBWOXXNCCSABA-JFLUISNFSA-N
InChi Code: InChI=1S/C27H26N8O12S/c1-27(2,25(45)46)47-32-17(14-9-48-26(28)31-14)20(39)30-13-8-33-7-12(18(24(43)44)35(33)23(13)42)19(38)29-3-4-34-21(40)10-5-15(36)16(37)6-11(10)22(34)41/h5-6,9,13,36-37H,3-4,7-8H2,1-2H3,(H2,28,31)(H,29,38)(H,30,39)(H,43,44)(H,45,46)/b32-17-/t13-/m0/s1
SMILES Code: O=C(NCCN1C(C(C=C(O)C(O)=C2)=C2C1=O)=O)C3=C(C(O)=O)N4N(C[C@H](NC(/C(C5=CSC(N)=N5)=N\OC(C)(C(O)=O)C)=O)C4=O)C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 686.609 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Goldberg JA, Nguyen H, Kumar V, et al. A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli [published online ahead of print, 2020 Jun 2]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00255. doi:10.1021/acs.jmedchem.0c00255