WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 534804

CAS#: 52694-55-0

Description: MT-45 is a bioactive chemical.

Chemical Structure

CAS# 52694-55-0

Theoretical Analysis

MedKoo Cat#: 534804
Name: MT-45
CAS#: 52694-55-0
Chemical Formula: C24H32N2
Exact Mass: 348.2565
Molecular Weight: 348.534
Elemental Analysis: C, 82.71; H, 9.25; N, 8.04

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MT-45; MT 45; MT45

IUPAC/Chemical Name: Piperazine, 1-cyclohexyl-4-(1,2-diphenylethyl)-, (+-)-


InChi Code: InChI=1S/C24H32N2/c1-4-10-21(11-5-1)20-24(22-12-6-2-7-13-22)26-18-16-25(17-19-26)23-14-8-3-9-15-23/h1-2,4-7,10-13,23-24H,3,8-9,14-20H2


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 348.534 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1: McKenzie C, Sutcliffe OB, Read KD, Scullion P, Epemolu O, Fletcher D, Helander A, Beck O, Rylski A, Antonides LH, Riley J, Smith SA, Nic Daeid N. Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users. Forensic Toxicol. 2018;36(2):359-374. doi: 10.1007/s11419-018-0413-1. Epub 2018 Apr 5. PMID: 29963206; PMCID: PMC6002428.

2: Montesano C, Vannutelli G, Fanti F, Vincenti F, Gregori A, Rita Togna A, Canazza I, Marti M, Sergi M. Identification of MT-45 Metabolites: In Silico Prediction, In Vitro Incubation with Rat Hepatocytes and In Vivo Confirmation. J Anal Toxicol. 2017 Oct 1;41(8):688-697. doi: 10.1093/jat/bkx058. PMID: 28985323.

3: Helander A, Bäckberg M, Beck O. MT-45, a new psychoactive substance associated with hearing loss and unconsciousness. Clin Toxicol (Phila). 2014 Sep-Oct;52(8):901-4. doi: 10.3109/15563650.2014.943908. Epub 2014 Sep 1. PMID: 25175898.

4: Helander A, Bradley M, Lapins J; all authors. 'Adulterant or contaminant in MT-45, or coingestion?' Reply from the authors. Br J Dermatol. 2017 Aug;177(2):582-583. doi: 10.1111/bjd.15638. Epub 2017 Jun 19. PMID: 28481453.

5: Baptista-Hon DT, Smith M, Singleton S, Antonides LH, Nic Daeid N, McKenzie C, Hales TG. Activation of μ-opioid receptors by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its fluorinated derivatives. Br J Pharmacol. 2020 Apr 4. doi: 10.1111/bph.15064. Epub ahead of print. PMID: 32246840.

6: Usui K, Murata T, Fujita Y, Kamijo Y, Hanazawa T, Yoshizawa T, Funayama M. Direct detection of the psychoactive substance MT-45 in human tissue samples by probe electrospray ionization-tandem mass spectrometry. Drug Test Anal. 2018 Jun;10(6):1033-1038. doi: 10.1002/dta.2390. Epub 2018 May 3. PMID: 29669397.

7: Bilel S, Azevedo NJ, Arfè R, Tirri M, Gregori A, Serpelloni G, De-Giorgio F, Frisoni P, Neri M, Calò G, Marti M. In vitro and in vivo pharmacological characterization of the synthetic opioid MT-45. Neuropharmacology. 2020 Jul;171:108110. doi: 10.1016/j.neuropharm.2020.108110. Epub 2020 Apr 25. PMID: 32344007.

8: Papsun D, Krywanczyk A, Vose JC, Bundock EA, Logan BK. Analysis of MT-45, a Novel Synthetic Opioid, in Human Whole Blood by LC-MS-MS and its Identification in a Drug-Related Death. J Anal Toxicol. 2016 May;40(4):313-7. doi: 10.1093/jat/bkw012. PMID: 27091064.

9: Beardsley PM, Zhang Y. Synthetic Opioids. Handb Exp Pharmacol. 2018;252:353-381. doi: 10.1007/164_2018_149. PMID: 30242482.

10: Concheiro M, Chesser R, Pardi J, Cooper G. Postmortem Toxicology of New Synthetic Opioids. Front Pharmacol. 2018 Oct 26;9:1210. doi: 10.3389/fphar.2018.01210. PMID: 30416445; PMCID: PMC6212520.

11: Drug Enforcement Administration, Department of Justice.. Schedules of Controlled Substances: Placement of MT-45 Into Schedule I. Final order. Fed Regist. 2017 Dec 13;82(238):58557-9. PMID: 29235771.

12: Wallach JV, Morris H, Brandt SD. Is nitrogen mustard contamination responsible for the reported MT-45 toxicity? Br J Dermatol. 2017 Aug;177(2):594-595. doi: 10.1111/bjd.15507. Epub 2017 Jul 2. PMID: 28369837.

13: Siddiqi S, Verney C, Dargan P, Wood DM. Understanding the availability, prevalence of use, desired effects, acute toxicity and dependence potential of the novel opioid MT-45. Clin Toxicol (Phila). 2015 Jan;53(1):54-9. doi: 10.3109/15563650.2014.983239. Epub 2014 Nov 28. PMID: 25430506.

14: Lindeman E, Bäckberg M, Personne M, Helander A. MT-45 - en livsfarlig och potentiellt ototoxisk internetdrog [MT-45--a dangerous and potentially ototoxic internet drug]. Lakartidningen. 2014 Sep 11;111(40):1712-5. Swedish. PMID: 25253604.

15: Fels H, Krueger J, Sachs H, Musshoff F, Graw M, Roider G, Stoever A. Two fatalities associated with synthetic opioids: AH-7921 and MT-45. Forensic Sci Int. 2017 Aug;277:e30-e35. doi: 10.1016/j.forsciint.2017.04.003. Epub 2017 Apr 15. PMID: 28506719.

16: Yip L, Deng JF. Adulterant or contaminant in MT-45, or coingestion? Br J Dermatol. 2017 Aug;177(2):582. doi: 10.1111/bjd.15629. Epub 2017 Jun 18. PMID: 28477377.

17: Helander A, Bradley M, Lapins J; all authors. 'Is nitrogen mustard contamination responsible for the reported MT-45 toxicity?' Reply from the authors. Br J Dermatol. 2017 Aug;177(2):595. doi: 10.1111/bjd.15676. Epub 2017 Jun 19. PMID: 28626874.

18: Yu V, Juhász M, Chiang A, Atanaskova Mesinkovska N. Alopecia and Associated Toxic Agents: A Systematic Review. Skin Appendage Disord. 2018 Oct;4(4):245-260. doi: 10.1159/000485749. Epub 2018 Jan 5. PMID: 30410891; PMCID: PMC6219226.

19: Drummer OH. Fatalities caused by novel opioids: a review. Forensic Sci Res. 2018 May 7;4(2):95-110. doi: 10.1080/20961790.2018.1460063. PMID: 31304441; PMCID: PMC6609322.

20: Baumann MH, Majumdar S, Le Rouzic V, Hunkele A, Uprety R, Huang XP, Xu J, Roth BL, Pan YX, Pasternak GW. Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace. Neuropharmacology. 2018 May 15;134(Pt A):101-107. doi: 10.1016/j.neuropharm.2017.08.016. Epub 2017 Aug 12. PMID: 28807672; PMCID: PMC5809328.