C-171 STING inhibitor
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MedKoo CAT#: 574317

CAS#: 2244881-69-2

Description: C-171 STING inhibitor is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.


Chemical Structure

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C-171 STING inhibitor
CAS# 2244881-69-2

Theoretical Analysis

MedKoo Cat#: 574317
Name: C-171 STING inhibitor
CAS#: 2244881-69-2
Chemical Formula: C17H20N2O4
Exact Mass: 316.1423
Molecular Weight: 316.36
Elemental Analysis: C, 64.54; H, 6.37; N, 8.86; O, 20.23

Price and Availability

Size Price Availability Quantity
10.0mg USD 225.0 2 Weeks
25.0mg USD 400.0 2 Weeks
50.0mg USD 630.0 2 Weeks
100.0mg USD 940.0 2 Weeks
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Synonym: C-171, C-171 STING inhibitor

IUPAC/Chemical Name: N-(4-hexylphenyl)-5-nitro-2-furancarboxamide

InChi Key: WZVGWJZGQFSRBG-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N2O4/c1-2-3-4-5-6-13-7-9-14(10-8-13)18-17(20)15-11-12-16(23-15)19(21)22/h7-12H,2-6H2,1H3,(H,18,20)

SMILES Code: O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(CCCCCC)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 316.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Haag, S.M., Gulen, M.F., Reymond, L., et al. Targeting STING with covalent small-molecule inhibitors. Nature 559(7713), 269-273 (2018).

2. Zhang, H., You, Q.-D., and Xu, X.-L. Targeting stimulator of interferon genes (STING): A medicinal chemistry perspective. J. Med. Chem. 63(8), 3785-3816 (2019).