iFSP1
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MedKoo CAT#: 462158

CAS#: 150651-39-1

Description: iFSP1 is a ferroptosis suppressor protein 1 (FSP1) inhibitor and ferroptosis inducer.

Chemical Structure

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iFSP1
CAS# 150651-39-1
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 462158
Name: iFSP1
CAS#: 150651-39-1
Chemical Formula: C20H13N5
Exact Mass: 323.12
Molecular Weight: 323.359
Elemental Analysis: C, 74.29; H, 4.05; N, 21.66

Price and Availability

Size Price Availability Quantity
10mg USD 80 Ready to ship
25mg USD 150 Ready to ship
50mg USD 250 Ready to ship
100mg USD 425 Ready to ship
200mg USD 750 Ready to ship
500mg USD 1450 Ready to ship
1g USD 2650 2 Weeks
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Synonym: iFSP1; iFSP-1; iFSP 1;

IUPAC/Chemical Name: 1-amino-3-(p-tolyl)benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile

InChi Key: FNESYDFRCQEEKA-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H13N5/c1-12-6-8-13(9-7-12)18-14(10-21)19(23)25-17-5-3-2-4-16(17)24-20(25)15(18)11-22/h2-9H,23H2,1H3

SMILES Code: NC1=C(C#N)C(C2=CC=C(C)C=C2)=C(C#N)C3=NC4=C(C=CC=C4)N31

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.0 92.78

Preparing Stock Solutions

The following data is based on the product molecular weight 323.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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Reconstitution Calculator

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1: Doll, S., Freitas, F.P., Shah, R., et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575(7784), 693-698 (2019).