MS 347a

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 534797

CAS#: 144678-18-2

Description: MS 347a is a myosin light chain kinase (MLCK) inhibitor; an epoxide analog of sydowinin B (MS-347b).


Chemical Structure

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MS 347a
CAS# 144678-18-2

Theoretical Analysis

MedKoo Cat#: 534797
Name: MS 347a
CAS#: 144678-18-2
Chemical Formula: C16H12O7
Exact Mass: 316.0583
Molecular Weight: 316.265
Elemental Analysis: C, 60.76; H, 3.82; O, 35.41

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MS 347a; MS-347a; MS347a

IUPAC/Chemical Name: 9bH-Oxireno(a)xanthene-9b-carboxylic acid, 1a,9-dihydro-8-hydroxy-6-(hydroxymethyl)-9-oxo-, methyl ester

InChi Key: DYSASOJNGXSFHH-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12O7/c1-21-15(20)16-11(23-16)3-2-9-13(16)14(19)12-8(18)4-7(6-17)5-10(12)22-9/h2-5,11,17-18H,6H2,1H3

SMILES Code: O=C(C12C(C3=O)=C(OC4=C3C(O)=CC(CO)=C4)C=CC1O2)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 316.265 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nakanishi S, Ando K, Kawamoto I, Matsuda Y. MS-347a, a new inhibitor of myosin light chain kinase from Aspergillus sp. KY52178. J Antibiot (Tokyo). 1993 Dec;46(12):1775-81. doi: 10.7164/antibiotics.46.1775. Erratum in: J Antibiot (Tokyo) 1994 Apr;47(4):C-2. PMID: 8294233.

2: Rao K, Paik WY, Zheng L, Jobin RM, Tomić M, Jiang H, Nakanishi S, Stojilkovic SS. Wortmannin-sensitive and -insensitive steps in calcium-controlled exocytosis in pituitary gonadotrophs: evidence that myosin light chain kinase mediates calcium-dependent and wortmannin-sensitive gonadotropin secretion. Endocrinology. 1997 Apr;138(4):1440-9. doi: 10.1210/endo.138.4.5078. PMID: 9075700.

3: Nakanishi S, Catt KJ, Balla T. Inhibition of agonist-stimulated inositol 1,4,5-trisphosphate production and calcium signaling by the myosin light chain kinase inhibitor, wortmannin. J Biol Chem. 1994 Mar 4;269(9):6528-35. PMID: 8120005.