MS 28

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 534790

CAS#: 117523-45-2

Description: MS 28 reverses both the respiratory depressant & antinociceptive effects of morphine.


Chemical Structure

img
MS 28
CAS# 117523-45-2

Theoretical Analysis

MedKoo Cat#: 534790
Name: MS 28
CAS#: 117523-45-2
Chemical Formula: C24H27N3O2
Exact Mass: 389.21
Molecular Weight: 389.499
Elemental Analysis: C, 74.01; H, 6.99; N, 10.79; O, 8.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MS 28; MS-28; MS28

IUPAC/Chemical Name: 2-Furancarboxamide, N-(4-methyl-2-pyridinyl)-N-(1-(2-phenylethyl)-4-piperidinyl)-

InChi Key: NQCPDEKEHVGSIN-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H27N3O2/c1-19-9-13-25-23(18-19)27(24(28)22-8-5-17-29-22)21-11-15-26(16-12-21)14-10-20-6-3-2-4-7-20/h2-9,13,17-18,21H,10-12,14-16H2,1H3

SMILES Code: O=C(C1=CC=CO1)N(C2=NC=CC(C)=C2)C3CCN(CCC4=CC=CC=C4)CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 389.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Msoka TF, Van Guilder GP, Smulders YM, van Furth M, Bartlett JA, van Agtmael MA. Association of HIV-infection, antiretroviral treatment and metabolic syndrome with large artery stiffness: a cross-sectional study. BMC Infect Dis. 2018 Dec 29;18(1):708. doi: 10.1186/s12879-018-3637-0. Erratum in: BMC Infect Dis. 2019 Feb 22;19(1):187. PMID: 30594160; PMCID: PMC6311066.


2: Deus LA, Sousa CV, Rosa TS, Filho JMS, Santos PA, Barbosa LD, Silva Aguiar S, Souza LHR, Simões HG. Heart rate variability in middle-aged sprint and endurance athletes. Physiol Behav. 2019 Jun 1;205:39-43. doi: 10.1016/j.physbeh.2018.10.018. Epub 2018 Oct 30. PMID: 30389479.


3: Kawamoto N, Fujita T, Fukushima S, Shimahara Y, Kume Y, Matsumoto Y, Yamashita K, Asakura K, Kobayashi J. Functional mitral stenosis after mitral valve repair for Type II dysfunction: determinants and impacts on long-term outcome. Eur J Cardiothorac Surg. 2018 Sep 1;54(3):453-459. doi: 10.1093/ejcts/ezy062. PMID: 29490023.


4: Abulaban A, Altowairqi A, Altowairqi H, Almutairi A, Altalhi S, Alotaibi F, Alabbadi I. Multiple Sclerosis Patients Knowledge in Saudi Arabia. Neurosciences (Riyadh). 2019 Oct;24(4):327-330. doi: 10.17712/nsj.2019.4.20190031. PMID: 31872816.


5: Peebles AT, Bruetsch AP, Lynch SG, Huisinga JM. Dynamic balance in persons with multiple sclerosis who have a falls history is altered compared to non- fallers and to healthy controls. J Biomech. 2017 Oct 3;63:158-163. doi: 10.1016/j.jbiomech.2017.08.023. Epub 2017 Sep 1. PMID: 28889946.


6: Wu X, Jhanji V, Chen H, Lin H, Zhang G, Brelen M, Chen W. Change in flash visual evoked potentials in New Zealand albino rabbits after sub-tenon's anesthesia. Cutan Ocul Toxicol. 2017 Jun;36(2):118-124. doi: 10.1080/15569527.2016.1189929. Epub 2016 Dec 13. PMID: 27838929.


7: Rusu LD, Cosma GG, Cernaianu SM, Marin MN, Rusu PF, Ciocănescu DP, Neferu FN. Tensiomyography method used for neuromuscular assessment of muscle training. J Neuroeng Rehabil. 2013 Jul 3;10:67. doi: 10.1186/1743-0003-10-67. PMID: 23822158; PMCID: PMC3713716.


8: Uyarel H, Uslu N, Okmen E, Tartan Z, Kasikcioglu H, Dayi SU, Cam N. QT dispersion in sarcoidosis. Chest. 2005 Oct;128(4):2619-25. doi: 10.1378/chest.128.4.2619. PMID: 16236934.


9: Ceccarelli A, Rocca MA, Pagani E, Colombo B, Martinelli V, Comi G, Filippi M. A voxel-based morphometry study of grey matter loss in MS patients with different clinical phenotypes. Neuroimage. 2008 Aug 1;42(1):315-22. doi: 10.1016/j.neuroimage.2008.04.173. Epub 2008 Apr 20. PMID: 18501636.


10: Nam BD, Kim SM, Jung HN, Kim Y, Choe YH. Comparison of quantitative imaging parameters using cardiovascular magnetic resonance between cardiac amyloidosis and hypertrophic cardiomyopathy: inversion time scout versus T1 mapping. Int J Cardiovasc Imaging. 2018 Nov;34(11):1769-1777. doi: 10.1007/s10554-018-1385-2. Epub 2018 May 30. PMID: 29846837.


11: Comabella M, Pradillo JM, Fernández M, Río J, Lizasoain I, Julià E, Moro MA, Sastre-Garriga J, Montalban X. Plasma levels of 15d-PGJ are not altered in multiple sclerosis. Eur J Neurol. 2009 Nov;16(11):1197-201. doi: 10.1111/j.1468-1331.2009.02696.x. Epub 2009 Jun 15. PMID: 19538219.


12: Bunting E, Lambrakos L, Kemper P, Whang W, Garan H, Konofagou E. Imaging the Propagation of the Electromechanical Wave in Heart Failure Patients with Cardiac Resynchronization Therapy. Pacing Clin Electrophysiol. 2017 Jan;40(1):35-45. doi: 10.1111/pace.12964. Epub 2016 Dec 2. PMID: 27790723; PMCID: PMC5266632.


13: O'Connell K, Langdon D, Tubridy N, Hutchinson M, McGuigan C. A preliminary validation of the brief international cognitive assessment for multiple sclerosis (BICAMS) tool in an Irish population with multiple sclerosis (MS). Mult Scler Relat Disord. 2015 Nov;4(6):521-5. doi: 10.1016/j.msard.2015.07.012. Epub 2015 Aug 7. PMID: 26590658.


14: Romão W, Sabino BD, Bueno MI, Vaz BG, Júnior AC, Maldaner AO, de Castro EV, Lordeiro RA, Nascentes CC, Eberlin MN, Augusti R. LSD and 9,10-dihydro-LSD analyses in street drug blotter samples via easy ambient sonic-spray ionization mass spectrometry (EASI-MS). J Forensic Sci. 2012 Sep;57(5):1307-12. doi: 10.1111/j.1556-4029.2012.02237.x. Epub 2012 Aug 6. PMID: 22880936.


15: Bi CF, Qian HR, Peng LJ, Mao LL, Huang X, Xia DY, Lei X, Qi XK. [The correlation factor analysis for conversion of clinically isolated syndrome to multiple sclerosis and neuromyelitis optica]. Zhonghua Nei Ke Za Zhi. 2016 Jun;55(6):460-5. Chinese. doi: 10.3760/cma.j.issn.0578-1426.2016.06.012. PMID: 27256609.


16: Roberto E, Braga AA, Papachristos AV. Closer to Guns: the Role of Street Gangs in Facilitating Access to Illegal Firearms. J Urban Health. 2018 Jun;95(3):372-382. doi: 10.1007/s11524-018-0259-1. PMID: 29744717; PMCID: PMC5993706.


17: Ryder RA, Kitano K, Phipps AM, Enyart MR, Koceja DM. Contralateral conditioning to the soleus H-reflex as a function of age and physical activity. Exp Brain Res. 2016 Jan;234(1):13-23. doi: 10.1007/s00221-015-4430-6. Epub 2015 Sep 10. PMID: 26358124.


18: Fritz NE, Newsome SD, Eloyan A, Marasigan RE, Calabresi PA, Zackowski KM. Longitudinal relationships among posturography and gait measures in multiple sclerosis. Neurology. 2015 May 19;84(20):2048-56. doi: 10.1212/WNL.0000000000001580. Epub 2015 Apr 15. PMID: 25878185; PMCID: PMC4442106.


19: Hughes JR, Stone JL, Fino JJ, Hart LA. Usefulness of different stimuli in visual evoked potentials. Neurology. 1987 Apr;37(4):656-62. doi: 10.1212/wnl.37.4.656. PMID: 3561778.


20: Villar LM, Masjuan J, González-Porqué P, Plaza J, Sádaba MC, Roldán E, Bootello A, Alvarez-Cermeño JC. Intrathecal IgM synthesis in neurologic diseases: relationship with disability in MS. Neurology. 2002 Mar 12;58(5):824-6. doi: 10.1212/wnl.58.5.824. PMID: 11889253.