WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555795
CAS#: 1394371-75-5
Description: DUN71755, also known as nAChR agonist 1, is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). DUN71755 is reported in WO 2012114285. DUN71755 has CAS#1394371-75-5, no formal name. For the convenience of scientific communication, we named it as DUN71755 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature (https://hodoodo.com/hodoodo-chemical-nomenclature).
MedKoo Cat#: 555795
Name: DUN71755
CAS#: 1394371-75-5
Chemical Formula: C20H18ClNO3S2
Exact Mass: 419.0417
Molecular Weight: 419.938
Elemental Analysis: C, 57.20; H, 4.32; Cl, 8.44; N, 3.34; O, 11.43; S, 15.27
Synonym: nAChR agonist 1; DUN71755; DUN 71755; DUN-71755;
IUPAC/Chemical Name: 4-(5-(4-chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide
InChi Key: DYIIYIJHDMIABW-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H18ClNO3S2/c1-3-17(23)20-18(13-6-10-16(11-7-13)27(22,24)25)12(2)19(26-20)14-4-8-15(21)9-5-14/h4-11H,3H2,1-2H3,(H2,22,24,25)
SMILES Code: NS(C1=CC=C(C2=C(C(CC)=O)SC(C3=CC=C(Cl)C=C3)=C2C)C=C1)(=O)=O
Sinha N, et al.Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization. J Med Chem. 2020 Feb 13;63(3):944-960.
