WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555794
CAS#: 1386162-69-1
Description: ML417 is a Highly Selective D3 Dopamine Receptor Agonist. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. Screening of ML417 against multiple G protein-coupled receptors revealed exceptional global selectivity. Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity. ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs.
MedKoo Cat#: 555794
Name: ML417
CAS#: 1386162-69-1
Chemical Formula: C22H25N3O3
Exact Mass: 379.1896
Molecular Weight: 379.46
Elemental Analysis: C, 69.64; H, 6.64; N, 11.07; O, 12.65
Synonym: ML417; ML-417; ML 417;
IUPAC/Chemical Name: 1H-Indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]methanone
InChi Key: HAZPAMUWUHDPDA-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H25N3O3/c1-27-18-6-8-19(9-7-18)28-15-14-24-10-12-25(13-11-24)22(26)21-16-17-4-2-3-5-20(17)23-21/h2-9,16,23H,10-15H2,1H3
SMILES Code: O=C(C(N1)=CC2=C1C=CC=C2)N3CCN(CCOC4=CC=C(OC)C=C4)CC3
Moritz AE, Free RB, Weiner WS, et al. Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. J Med Chem. 2020;63(10):5526‐5567. doi:10.1021/acs.jmedchem.0c00424
