Westiellamide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462093

CAS#: 131998-54-4

Description: Westiellamide is a a bistratamide-related cyclic peptide from the blue-green alga westiellopsis prolifica.

Chemical Structure

img
Westiellamide
CAS# 131998-54-4
Instruction

Theoretical Analysis

MedKoo Cat#: 462093
Name: Westiellamide
CAS#: 131998-54-4
Chemical Formula: C27H42N6O6
Exact Mass: 546.32
Molecular Weight: 546.669
Elemental Analysis: C, 59.32; H, 7.74; N, 15.37; O, 17.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Westiellamide

IUPAC/Chemical Name: 6,13,20-Trioxa-3,10,17,22,23,24-hexaazatetracyclo(17.2.1.1(5,8).1(12,15))tetracosa-5(24),12(23),19(22)-triene-2,9,16-trione, 7,14,21-trimethyl-4,11,18-tris(1-methylethyl)-, (1S-(1R*,4R*,7S*,8R*,11R*,14S*,15R*,18R*,21S*))-

InChi Key: MIDTUAMKJJDHAR-YAWPOEEYSA-N

InChi Code: InChI=1S/C27H42N6O6/c1-10(2)16-25-31-20(13(7)37-25)23(35)29-18(12(5)6)27-33-21(15(9)39-27)24(36)30-17(11(3)4)26-32-19(14(8)38-26)22(34)28-16/h10-21H,1-9H3,(H,28,34)(H,29,35)(H,30,36)/t13-,14-,15-,16+,17+,18+,19+,20+,21+/m1/s1

SMILES Code: O=C(N[C@@H](C(C)C)C1=N[C@@](C(N[C@@H](C(C)C)C2=N[C@@](C(N[C@H]3C(C)C)=O)([H])[C@@H](C)O2)=O)([H])[C@@H](C)O1)[C@]4([H])[C@@H](C)OC3=N4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 546.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Mild Hypothermia Decreases Fentanyl and Midazolam Steady-State clearance in a Rat Model of Cardiac Arrest Philip E. Empey, Tricia M. Miller, Ashley H. Philbrick, John Melick, Patrick M. Kochanek, Samuel M. Poloyac Crit Care Med. Author manuscript; available in PMC 2013 Apr 1.Published in final edited form as: Crit Care Med. 2012 Apr; 40(4): 1221–1228. doi: 10.1097/CCM.0b013e31823779f9 PMCID: PMC3307845

2: Thiazole and Oxazole Alkaloids: Isolation and Synthesis Danilo Davyt, Gloria Serra Mar Drugs. 2010; 8(11): 2755–2780. Published online 2010 Nov 5. doi: 10.3390/md8112755 PMCID: PMC2996175

3: Bistratamides M and N, Oxazole-Thiazole Containing Cyclic Hexapeptides Isolated from Lissoclinum bistratum Interaction of Zinc (II) with Bistratamide K Carlos Urda, Rogelio Fernández, Jaime Rodríguez, Marta Pérez, Carlos Jiménez, Carmen Cuevas Mar Drugs. 2017 Jul; 15(7): 209. Published online 2017 Jul 1. doi: 10.3390/md15070209 PMCID: PMC5532651

4: Natural Products from Cyanobacteria: Focus on Beneficial Activities Justine Demay, Cécile Bernard, Anita Reinhardt, Benjamin Marie Mar Drugs. 2019 Jun; 17(6): 320. Published online 2019 May 30. doi: 10.3390/md17060320 PMCID: PMC6627551

5: Indole Alkaloids of the Stigonematales (Cyanophyta): Chemical Diversity, Biosynthesis and Biological Activity Katherine Walton, John P. Berry Mar Drugs. 2016 Apr; 14(4): 73. Published online 2016 Apr 6. doi: 10.3390/md14040073 PMCID: PMC4849077

6: Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria Melinda L. Micallef, Paul M. D’Agostino, Deepti Sharma, Rajesh Viswanathan, Michelle C. Moffitt BMC Genomics. 2015; 16(1): 669. Published online 2015 Sep 3. doi: 10.1186/s12864-015-1855-z PMCID: PMC4558948

7: Naturally Occurring Oxazole-Containing Peptides Jessica T. Mhlongo, Edikarlos Brasil, Beatriz G. de la Torre, Fernando Albericio Mar Drugs. 2020 Apr; 18(4): 203. Published online 2020 Apr 10. doi: 10.3390/md18040203 PMCID: PMC7231064

8: Marine Natural Product Peptides with Therapeutic Potential: Chemistry, Biosynthesis, and Pharmacology Vedanjali Gogineni, Mark T. Hamann Biochim Biophys Acta. Author manuscript; available in PMC 2019 Jan 1.Published in final edited form as: Biochim Biophys Acta. 2018 Jan; 1862(1): 81–196. Published online 2017 Aug 24. doi: 10.1016/j.bbagen.2017.08.014 PMCID: PMC5918664

9: Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria Kaarina Sivonen, Niina Leikoski, David P. Fewer, Jouni Jokela Appl Microbiol Biotechnol. 2010 May; 86(5): 1213–1225. Published online 2010 Feb 27. doi: 10.1007/s00253-010-2482-x PMCID: PMC2854353

10: Fluorocyclisation via I(I)/I(III) catalysis: a concise route to fluorinated oxazolines Felix Scheidt, Christian Thiehoff, Gülay Yilmaz, Stephanie Meyer, Constantin G Daniliuc, Gerald Kehr, Ryan Gilmour Beilstein J Org Chem. 2018; 14: 1021–1027. Published online 2018 May 9. doi: 10.3762/bjoc.14.88 PMCID: PMC6009682