IK187

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462073

CAS#: unknown

Description: IK187 is a nonpeptidic PAR2 agonist with submicromolar potency in a functional assay reflecting G protein activation. The ligand also showed substantial β-arrestin recruitment. IK187 shows preferable metabolic stability and may serve as a lead compound for the development of nonpeptidic drugs addressing PAR2.


Chemical Structure

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IK187
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 462073
Name: IK187
CAS#: unknown
Chemical Formula: C23H30N4O4
Exact Mass: 426.2267
Molecular Weight: 426.517
Elemental Analysis: C, 64.77; H, 7.09; N, 13.14; O, 15.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: IK187; IK-187; IK 187

IUPAC/Chemical Name: (S)-N-(1-((2-(2-amino-2-oxoethyl)benzyl)amino)-3-cyclohexyl-1-oxopropan-2-yl)-3-methylisoxazole-5-carboxamide

InChi Key: AOSPZDVYEJMNQD-IBGZPJMESA-N

InChi Code: InChI=1S/C23H30N4O4/c1-15-11-20(31-27-15)23(30)26-19(12-16-7-3-2-4-8-16)22(29)25-14-18-10-6-5-9-17(18)13-21(24)28/h5-6,9-11,16,19H,2-4,7-8,12-14H2,1H3,(H2,24,28)(H,25,29)(H,26,30)/t19-/m0/s1

SMILES Code: NC(CC1=CC=CC=C1CNC([C@H](CC2CCCCC2)NC(C3=CC(C)=NO3)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 426.517 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ilona Klösel, Maximilian F. Schmidt, Jonas Kaindl, Harald Hübner, Dorothee Weikert, and Peter Gmeiner. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Medicinal Chemistry Letters Article ASAP. DOI: 10.1021/acsmedchemlett.0c00154.