WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462072

CAS#: 2085271-43-6

Description: L0909 is an orally available inhibitors of Hepatitis C virus with a novel mechanism of action (EC50 = 0.022 μM, SI > 600). L0909 could block HCV replication by acting on the HCV entry stage. The high sensitivity to clinical resistant HCV mutants and synergistic effect with clinical drugs were observed for this compound. L0909 as a promising HCV entry inhibitor for single or combinational therapeutic potential.

Chemical Structure

CAS# 2085271-43-6

Theoretical Analysis

MedKoo Cat#: 462072
Name: L0909
CAS#: 2085271-43-6
Chemical Formula: C23H30ClN5
Exact Mass: 411.22
Molecular Weight: 411.978
Elemental Analysis: C, 67.06; H, 7.34; Cl, 8.60; N, 17.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L0909; L-0909; L 0909

IUPAC/Chemical Name: 2-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-4-((2-(dimethylamino)ethyl)(methyl)amino)benzonitrile


InChi Code: InChI=1S/C23H30ClN5/c1-26(2)10-11-27(3)23-7-4-19(17-25)20(16-23)18-28-12-14-29(15-13-28)22-8-5-21(24)6-9-22/h4-9,16H,10-15,18H2,1-3H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 411.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1:Xinbei Jiang, Jiali Tan, Yixuan Wang, Jinhua Chen, Jianrui Li, Zhi Jiang, Yanni Quan, Jie Jin, Yuhuan Li, Shan Cen, Yanping Li, Zonggen Peng, and Zhuorong Li. 2-((4-Arylpiperazin-1-yl)methyl)benzonitrile Derivatives as Orally Available Inhibitors of Hepatitis C Virus with a Novel Mechanism of Action. Journal of Medicinal Chemistry Article ASAP. DOI: 10.1021/acs.jmedchem.0c00232