WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555793
Description: LY-3381916, also known as IDO1-IN-5, is a potent, selective and brain penetrated DO1 inhibitor. LY3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, LY3381916 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).
MedKoo Cat#: 555793
Chemical Formula: C23H25FN2O3
Exact Mass: 396.1849
Molecular Weight: 396.4624
Elemental Analysis: C, 69.68; H, 6.36; F, 4.79; N, 7.07; O, 12.11
Synonym: LY-3381916; LY 3381916; LY 3381916; IDO1-IN-5; IDO1-IN-5; IDO1 IN-5; IDO1-IN5; IDO1IN5; IDO1 IN5;
IUPAC/Chemical Name: (R)-4-fluoro-N-(1-(1-(tetrahydro-2H-pyran-4-carbonyl)indolin-5-yl)ethyl)benzamide
InChi Key: NUBWFWVVKLRSHS-OAHLLOKOSA-N
InChi Code: InChI=1S/C23H25FN2O3/c1-15(25-22(27)16-2-5-20(24)6-3-16)18-4-7-21-19(14-18)8-11-26(21)23(28)17-9-12-29-13-10-17/h2-7,14-15,17H,8-13H2,1H3,(H,25,27)/t15-/m1/s1
SMILES Code: FC1=CC=C(C(N[C@H](C)C2=CC=C(N(C(C3CCOCC3)=O)CC4)C4=C2)=O)C=C1
Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells, thereby inhibiting the growth of IDO1-expressing tumor cells. IDO1, overexpressed by multiple tumor cell types, plays an important role in immunosuppression. Tryptophan depletion inhibits T-lymphocyte proliferation and activation, and subsequently suppresses the immune system.