BMVC-8C3O
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MedKoo CAT#: 555791

CAS#: 1301708-12-2

Description: BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 2 Weeks
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2950 2 Weeks
2g USD 5250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-20. Prices are subject to change without notice.

BMVC-8C3O is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555791
Name: BMVC-8C3O
CAS#: 1301708-12-2
Chemical Formula: C42H53I3N4O3
Exact Mass:
Molecular Weight: 1042.6244
Elemental Analysis: C, 48.38; H, 5.12; I, 36.51; N, 5.37; O, 4.60


Synonym: BMVC-8C3O; BMVC 8C3O; BMVC8C3O;

IUPAC/Chemical Name: 4,4'-((1E,1'E)-(9-(2-(2-(2-(2-(1-methylpiperidin-1-ium-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-9H-carbazole-3,6-diyl)bis(ethene-2,1-diyl))bis(1-methylpyridin-1-ium) iodide

InChi Key: DKMJOQQQBQBOMV-UHFFFAOYSA-K

InChi Code: InChI=1S/C42H53N4O3.3HI/c1-43-19-15-35(16-20-43)7-9-37-11-13-41-39(33-37)40-34-38(10-8-36-17-21-44(2)22-18-36)12-14-42(40)45(41)23-27-47-29-31-49-32-30-48-28-26-46(3)24-5-4-6-25-46;;;/h7-22,33-34H,4-6,23-32H2,1-3H3;3*1H/q+3;;;/p-3

SMILES Code: C[N+]1(CCOCCOCCOCCN2C3=C(C4=C2C=CC(/C=C/C5=CC=[N+](C)C=C5)=C4)C=C(/C=C/C6=CC=[N+](C)C=C6)C=C3)CCCCC1.[I-].[I-].[I-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

The folding topology of DNA G-quadruplexes (G4s) depends not only on their nucleotide sequences but also on environmental factors and/or ligand binding


References

1: Wang ZF, Li MH, Chen WW, Hsu ST, Chang TC. A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes. Nucleic Acids Res. 2016 May 5;44(8):3958-68. doi: 10.1093/nar/gkw145. Epub 2016 Mar 14. PMID: 26975658; PMCID: PMC4856992.

2: Wang ZF, Chang TC. Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol. Nucleic Acids Res. 2012 Sep 1;40(17):8711-20. doi: 10.1093/nar/gks578. Epub 2012 Jun 26. PMID: 22735707; PMCID: PMC3458535.