MS4
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 534620

CAS#: 1166869-57-3

Description: MS4 is a novel glucocorticoid receptor (GR) agonist with anti-inflammatory activity and displaying reduced impact on islets.

Chemical Structure

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MS4
CAS# 1166869-57-3
Instruction

Theoretical Analysis

MedKoo Cat#: 534620
Name: MS4
CAS#: 1166869-57-3
Chemical Formula: C28H33NO4S2
Exact Mass: 511.19
Molecular Weight: 511.695
Elemental Analysis: C, 65.72; H, 6.50; N, 2.74; O, 12.51; S, 12.53

Price and Availability

Size Price Availability Quantity
5mg USD 270 2 Weeks
25mg USD 650 2 Weeks
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Synonym: MS4; MS-4; MS 4

IUPAC/Chemical Name: (8S,9S,10R,11S,13S,14S,17R)-17-(2-(benzo[d]thiazol-2-ylthio)acetyl)-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

InChi Key: UMZHTAZBBMHXSX-ALCUMQOQSA-N

InChi Code: InChI=1S/C28H33NO4S2/c1-26-11-9-17(30)13-16(26)7-8-18-19-10-12-28(33,27(19,2)14-21(31)24(18)26)23(32)15-34-25-29-20-5-3-4-6-22(20)35-25/h3-6,13,18-19,21,24,31,33H,7-12,14-15H2,1-2H3/t18-,19-,21-,24+,26-,27-,28-/m0/s1

SMILES Code: O=C1CC[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C)[C@@](O)(C(CSC5=NC6=CC=CC=C6S5)=O)CC[C@@]4([H])[C@]3([H])CCC2=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 511.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Thu SW, Rai KM, Sandhu D, Rajangam A, Balasubramanian VK, Palmer RG, Mendu V. Mutation in a PHD-finger protein MS4 causes male sterility in soybean. BMC Plant Biol. 2019 Aug 28;19(1):378. doi: 10.1186/s12870-019-1979-4. PMID: 31455245; PMCID: PMC6712664.


2: Hasegawa Y, Ueno S, Matsumoto A, Ujino-Ihara T, Uchiyama K, Totsuka S, Iwai J, Hakamata T, Moriguchi Y. Fine mapping of the male-sterile genes (MS1, MS2, MS3, and MS4) and development of SNP markers for marker-assisted selection in Japanese cedar (Cryptomeria japonica D. Don). PLoS One. 2018 Nov 15;13(11):e0206695. doi: 10.1371/journal.pone.0206695. PMID: 30439978; PMCID: PMC6237302.


3: Nevares-Pomales OW, Sarriera-Lazaro CJ, Barrera-Llaurador J, Santiago-Vazquez M, Lugo-Fagundo N, Sanchez JE, Sanchez JL. Pigmented Lesions of the Nail Unit. Am J Dermatopathol. 2018 Nov;40(11):793-804. doi: 10.1097/DAD.0000000000001106. PMID: 30339563.


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5: Wang YC, Chen SJ, Huang PJ, Huang HT, Cheng YM, Shih CL. Efficacy of Different Energy Levels Used in Focused and Radial Extracorporeal Shockwave Therapy in the Treatment of Plantar Fasciitis: A Meta-Analysis of Randomized Placebo-Controlled Trials. J Clin Med. 2019 Sep 19;8(9):1497. doi: 10.3390/jcm8091497. PMID: 31546912; PMCID: PMC6780733.


6: Jongen PJ, Ter Horst AT, Brands AM. Cognitive impairment in multiple sclerosis. Minerva Med. 2012 Apr;103(2):73-96. PMID: 22513513.


7: Liu Q, Golubovskaya I, Cande WZ. Abnormal cytoskeletal and chromosome distribution in po, ms4 and ms6; mutant alleles of polymitotic that disrupt the cell cycle progression from meiosis to mitosis in maize. J Cell Sci. 1993 Dec;106 ( Pt 4):1169-78. PMID: 8126098.


8: Geske JA, Hartman T, Goodman B, Paulman P. Influence of a rural family medicine rotation on residency selection: MS3 versus MS4. Fam Med. 2011 Sep;43(8):556-9. PMID: 21918934.


9: Weusten B, Bisschops R, Coron E, Dinis-Ribeiro M, Dumonceau JM, Esteban JM, Hassan C, Pech O, Repici A, Bergman J, di Pietro M. Endoscopic management of Barrett's esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. Endoscopy. 2017 Feb;49(2):191-198. doi: 10.1055/s-0042-122140. Epub 2017 Jan 25. PMID: 28122386.


10: Li W, Feng Y, Zhang L, Xiao L. Potential impacts of host specificity on zoonotic or interspecies transmission of Enterocytozoon bieneusi. Infect Genet Evol. 2019 Nov;75:104033. doi: 10.1016/j.meegid.2019.104033. Epub 2019 Sep 5. PMID: 31494271.