Watanipidine monohydrochloride

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462034

CAS#: 116308-56-6

Description: Watanipidine monohydrochloride is a is a calcium channel antagonist. It is used in the research of hypertensive disease.

Chemical Structure

Watanipidine monohydrochloride

CAS# 116308-56-6

Instruction

Theoretical Analysis

MedKoo Cat#: 462034
Name: Watanipidine monohydrochloride
CAS#: 116308-56-6
Chemical Formula: C41H43ClN4O6
Exact Mass: 722.29
Molecular Weight: 723.267
Elemental Analysis: C, 68.09; H, 5.99; Cl, 4.90; N, 7.75; O, 13.27

Price and Availability

Size	Price	Availability
100mg	USD -1	2 Weeks
250mg	USD -1	2 Weeks
500mg	USD -1	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Watanipidine monohydrochloride; Watanipidine HCl; AE0047

IUPAC/Chemical Name: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(4-(diphenylmethyl)-1-piperazinyl)phenyl)ethyl methyl ester, monohydrochloride

InChi Key: HEKGFDAQKCYYLS-UHFFFAOYSA-N

InChi Code: InChI=1S/C41H42N4O6.ClH/c1-28-36(40(46)50-3)38(33-15-10-16-35(27-33)45(48)49)37(29(2)42-28)41(47)51-26-21-30-17-19-34(20-18-30)43-22-24-44(25-23-43)39(31-11-6-4-7-12-31)32-13-8-5-9-14-32;/h4-20,27,38-39,42H,21-26H2,1-3H3;1H

SMILES Code: O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCC3=CC=C(N4CCN(C(C5=CC=CC=C5)C6=CC=CC=C6)CC4)C=C3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 723.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ashimori A, Ono T, Inoue Y, et al. Novel 1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive activity of 3-[4-(substituted amino)phenylalkyl]ester derivatives. Chem Pharm Bull (Tokyo). 1991;39(1):91‐99. doi:10.1248/cpb.39.91

2: Ashimori A, Uchida T, Ohtaki Y, et al. Synthesis and pharmacological effects of optically active 2-[4-(4-benzhydryl-1-piperazinyl)phenyl]-ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride. Chem Pharm Bull (Tokyo). 1991;39(1):108‐111. doi:10.1248/cpb.39.108.

3: Yamanaga K, Shinyama H, Akira T, et al. AE0047-mediated calcium channel blocking in vascular smooth muscles. Gen Pharmacol. 1997;29(3):337‐343. doi:10.1016/s0306-3623(96)00515-0.

4: Nishikawa M, Kubo Y, Kido H, Nakayama T, Nakamura N. Protection against endothelial abnormalities by a novel calcium channel blocker, AE0047, in stroke-prone spontaneously hypertensive rats. Gen Pharmacol. 1999;32(3):299‐305. doi:10.1016/s0306-3623(98)00180-3

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