WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462032

CAS#: 125292-97-9

Description: Wallichinine is a PAF antagonist that is isolated and purified from the stem of Piper wallichii. Wallichinine can significantly potentiate the effects of two ABCB1, substrates vincristine and doxorubicin, on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells.

Chemical Structure

CAS# 125292-97-9

Theoretical Analysis

MedKoo Cat#: 462032
Name: Wallichinine
CAS#: 125292-97-9
Chemical Formula: C22H26O5
Exact Mass: 370.18
Molecular Weight: 370.445
Elemental Analysis: C, 71.33; H, 7.07; O, 21.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Wallichinine

IUPAC/Chemical Name: (Z)-2-allyl-4-(1-(3,4-dimethoxyphenyl)prop-1-en-2-yl)-4,5-dimethoxycyclohexa-2,5-dien-1-one


InChi Code: InChI=1S/C22H26O5/c1-7-8-17-14-22(27-6,21(26-5)13-18(17)23)15(2)11-16-9-10-19(24-3)20(12-16)25-4/h7,9-14H,1,8H2,2-6H3/b15-11-

SMILES Code: C=CCC(C(C=C1OC)=O)=CC1(OC)/C(C)=C([H])\C2=CC(OC)=C(OC)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 370.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wallichinine reverses ABCB1-mediated cancer multidrug resistance Min Lv, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Wu-Ming Qin, Yang Yang, Di-Wei Zheng, Yao Chen, Jia-Rong Huang, Kun Wang, Meng-Ning Wei, Ke-Jun Cheng, Zhi Shi Am J Transl Res. 2016; 8(7): 2969–2980. Published online 2016 Jul 15. PMCID: PMC4969433.