WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462032
Description: Wallichinine is a PAF antagonist that is isolated and purified from the stem of Piper wallichii. Wallichinine can significantly potentiate the effects of two ABCB1, substrates vincristine and doxorubicin, on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells.
MedKoo Cat#: 462032
Chemical Formula: C22H26O5
Exact Mass: 370.178
Molecular Weight: 370.445
Elemental Analysis: C, 71.33; H, 7.07; O, 21.59
This product is not in stock, which may be available by custom synthesis.
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IUPAC/Chemical Name: (Z)-2-allyl-4-(1-(3,4-dimethoxyphenyl)prop-1-en-2-yl)-4,5-dimethoxycyclohexa-2,5-dien-1-one
InChi Key: VKYZYTYFGUQBLS-PTNGSMBKSA-N
InChi Code: InChI=1S/C22H26O5/c1-7-8-17-14-22(27-6,21(26-5)13-18(17)23)15(2)11-16-9-10-19(24-3)20(12-16)25-4/h7,9-14H,1,8H2,2-6H3/b15-11-
SMILES Code: C=CCC(C(C=C1OC)=O)=CC1(OC)/C(C)=C([H])\C2=CC(OC)=C(OC)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 370.445 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wallichinine reverses ABCB1-mediated cancer multidrug resistance Min Lv, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Wu-Ming Qin, Yang Yang, Di-Wei Zheng, Yao Chen, Jia-Rong Huang, Kun Wang, Meng-Ning Wei, Ke-Jun Cheng, Zhi Shi Am J Transl Res. 2016; 8(7): 2969–2980. Published online 2016 Jul 15. PMCID: PMC4969433.