Tac 278

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462010

CAS#: 65906-75-4

Description: Tac 278 is a prodrug of 5-fluorouracil.

Chemical Structure

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Tac 278
CAS# 65906-75-4
Instruction

Theoretical Analysis

MedKoo Cat#: 462010
Name: Tac 278
CAS#: 65906-75-4
Chemical Formula: C11H17FN2O5
Exact Mass: 276.11
Molecular Weight: 276.264
Elemental Analysis: C, 47.82; H, 6.20; F, 6.88; N, 10.14; O, 28.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Tac 278, Tac-278; NSC 375520

IUPAC/Chemical Name: ethyl 4-butoxy-5-fluoro-2,6-dioxo-1,3-diazinane-5-carboxylate

InChi Key: QYIJQWZDUJULHZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H17FN2O5/c1-3-5-6-19-8-11(12,9(16)18-4-2)7(15)13-10(17)14-8/h8H,3-6H2,1-2H3,(H2,13,14,15,17)

SMILES Code: O=C(C1(F)C(OCCCC)NC(NC1=O)=O)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 276.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: NFKB1 Promoter DNA from nt+402 to nt+99 Is Hypomethylated in Different Human Immune Cells
Matthias Unterberg, Maxmiliane Julia Kreuzer, Simon Thomas Schäfer, Zainab Bazzi, Michael Adamzik, Katharina Rump PLoS One. 2016; 11(6): e0156702. Published online 2016 Jun 1. doi: 10.1371/journal.pone.0156702 PMCID: PMC4889142

2: Cloning, sequence and expression of rat cathepsin D. N P Birch, Y P Loh Nucleic Acids Res. 1990 Nov 11; 18(21): 6445–6446. doi: 10.1093/nar/18.21.6445 PMCID: PMC332560

3: Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing Stefan Taudien, Marco Groth, Klaus Huse, Andreas Petzold, Karol Szafranski, Jochen Hampe, Philip Rosenstiel, Stefan Schreiber, Matthias Platzer BMC Genomics. 2010; 11: 252. Published online 2010 Apr 19. doi: 10.1186/1471-2164-11-252 PMCID: PMC2873476