Tabernanthine hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462007

CAS#: 5990-60-3 (HCl)

Description: Tabernanthine hydrochloride is a naturally occurring, psychoactive indole alkaloid derived from the root bark of the African shrub Tabernanthe iboga.

Chemical Structure

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Tabernanthine hydrochloride
CAS# 5990-60-3 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 462007
Name: Tabernanthine hydrochloride
CAS#: 5990-60-3 (HCl)
Chemical Formula: C20H27ClN2O
Exact Mass: 346.18
Molecular Weight: 346.899
Elemental Analysis: C, 69.25; H, 7.85; Cl, 10.22; N, 8.08; O, 4.61

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 83-94-3 (free base)   5990-60-3 (HCl),  

Synonym: Tabernanthine hydrochloride

IUPAC/Chemical Name: (6R,6aS,7S,9R)-7-ethyl-3-methoxy-6,6a,7,8,9,10,12,13-octahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole hydrochloride

InChi Key: DRXPUXOQWQMVBQ-ISYVNWANSA-N

InChi Code: InChI=1S/C20H26N2O.ClH/c1-3-13-8-12-9-17-19-16(6-7-22(11-12)20(13)17)15-5-4-14(23-2)10-18(15)21-19;/h4-5,10,12-13,17,20-21H,3,6-9,11H2,1-2H3;1H/t12-,13+,17+,20+;/m1./s1

SMILES Code: CC[C@@]([C@@]12[H])([H])C[C@]3([H])C[C@@]1([H])C4=C(C5=C(N4)C=C(OC)C=C5)CCN2C3.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 346.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ibogaine Acute Administration in Rats Promotes Wakefulness, Long-Lasting REM Sleep Suppression, and a Distinctive Motor Profile Joaquín González, José P. Prieto, Paola Rodríguez, Matías Cavelli, Luciana Benedetto, Alejandra Mondino, Mariana Pazos, Gustavo Seoane, Ignacio Carrera, Cecilia Scorza, Pablo Torterolo Front Pharmacol. 2018; 9: 374. Published online 2018 Apr 27. doi: 10.3389/fphar.2018.00374 PMCID: PMC5934978

2: The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation Xaver Koenig, Karlheinz Hilber
Molecules. 2015 Feb; 20(2): 2208–2228. Published online 2015 Jan 29. doi: 10.3390/molecules20022208 PMCID: PMC4382526

3: Ibogaine and addiction in the animal model, a systematic review and meta-analysis M Belgers, M Leenaars, J R Homberg, M Ritskes-Hoitinga, A F A Schellekens, C R Hooijmans Transl Psychiatry. 2016 May; 6(5): e826. Published online 2016 May 31. doi: 10.1038/tp.2016.71 PMCID: PMC5545647

4: Studies on the pharmacology of conopharyngine, an indole alkaloid of the voacanga series. P R Carroll, G A Starmer Br J Pharmacol Chemother. 1967 May; 30(1): 173–185. doi: 10.1111/j.1476-5381.1967.tb02123.x PMCID: PMC1557242

5: Development of QSAR model for immunomodulatory activity of natural coumarinolignoids Dharmendra K Yadav, Abha Meena, Ankit Srivastava, D Chanda, Feroz Khan, SK Chattopadhyay Drug Des Devel Ther. 2010; 4: 173–186. Published online 2010 Sep 7. doi: 10.2147/dddt.s10875 PMCID: PMC2939762