6-Chloroguanine
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MedKoo CAT#: 461978

CAS#: 10310-21-1

Description: 6-Chloroguanine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).


Chemical Structure

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6-Chloroguanine
CAS# 10310-21-1

Theoretical Analysis

MedKoo Cat#: 461978
Name: 6-Chloroguanine
CAS#: 10310-21-1
Chemical Formula: C5H4ClN5
Exact Mass: 169.0155
Molecular Weight: 169.572
Elemental Analysis: C, 35.42; H, 2.38; Cl, 20.91; N, 41.30

Price and Availability

Size Price Availability Quantity
1.0g USD 215.0 2 Weeks
5.0g USD 386.0 2 Weeks
10.0g USD 625.0 2 Weeks
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Synonym: 6-Chloroguanine; 2-Amino-6-chloropurine; NSC 29570; 6-Chloro-1H-purin-2-amine

IUPAC/Chemical Name: 1H-Purin-2-amine, 6-chloro- (9CI)

InChi Key: RYYIULNRIVUMTQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)

SMILES Code: NC1=NC2=NC=NC2=C(Cl)N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 169.572 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mondal S, Puranik M. Sub-50 fs excited state dynamics of 6-chloroguanine upon deep ultraviolet excitation. Phys Chem Chem Phys. 2016 May 18;18(20):13874-87. doi: 10.1039/c6cp01746k. PubMed PMID: 27146198.

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6: Keough DT, Skinner-Adams T, Jones MK, Ng AL, Brereton IM, Guddat LW, de Jersey J. Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases. J Med Chem. 2006 Dec 14;49(25):7479-86. PubMed PMID: 17149876.

7: Mondal S, Puranik M. Ultrafast structural dynamics of photoexcited adenine. Phys Chem Chem Phys. 2017 Aug 2;19(30):20224-20240. doi: 10.1039/c7cp03092d. PubMed PMID: 28726897.

8: Mahajan TR, Ytre-Arne ME, Strøm-Andersen P, Dalhus B, Gundersen LL. Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1. Molecules. 2015 Sep 2;20(9):15944-65. doi:10.3390/molecules200915944. PubMed PMID: 26364627; PubMed Central PMCID: PMC6332111.

9: Kröplin T, Fischer C, Iven H. Inhibition of thiopurine S-methyltransferase activity by impurities in commercially available substrates: a factor for differing results of TPMT measurements. Eur J Clin Pharmacol. 1999 Jun;55(4):285-91. PubMed PMID: 10424321.

10: Ashby J, Paton D, Styles JA, Greatbanks D, Wright B. Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the reaction of ethylene oxide (EO) with DNA. Mutat Res. 1982 Mar;103(3-6):257-61. PubMed PMID:7087988.

11: Wang X, Qiu H, Liu X, Jiang S. [Separation of bases, phenols and pharmaceuticals on ionic liquid-modified silica stationary phase with pure water as mobile phase]. Se Pu. 2011 Mar;29(3):269-72. Chinese. PubMed PMID: 21657060