WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 593199
CAS#: unknown
Description: PVHD303 is a potent anticancer agent. It inhibits the growth of tumors dose-dependently in the HCT116 human colon cancer xenograft model in vivo.
MedKoo Cat#: 593199
Name: PVHD303
CAS#: unknown
Chemical Formula: C21H18N2O3
Exact Mass: 346.1317
Molecular Weight: 346.386
Elemental Analysis: C, 72.82; H, 5.24; N, 8.09; O, 13.86
This product is not in stock, which may be available by custom synthesis.
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Synonym: PVHD303; PVHD-303; PVHD-303
IUPAC/Chemical Name: 1-(2-(furan-3-yl)quinazolin-4-yl)-1-(4-methoxyphenyl)ethan-1-ol
InChi Key: USLHJGWCQIJIGV-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H18N2O3/c1-21(24,15-7-9-16(25-2)10-8-15)19-17-5-3-4-6-18(17)22-20(23-19)14-11-12-26-13-14/h3-13,24H,1-2H3
SMILES Code: CC(C1=CC=C(OC)C=C1)(C2=C3C=CC=CC3=NC(C4=COC=C4)=N2)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 346.386 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Yumiko Suzuki, Ayana Otake, Satoshi Ueno, Kensuke Hayashi, Hirosuke Ishii, Nao Miyoshi, Kenta Kuroiwa, Masashi Tachikawa,Yuki Fujimak, Kotaro Nishiyama, Kei Manabe, Ryuta Yamazaki, Akira Asai. Discovery of a Potent Anticancer Agent PVHD303 with in Vivo Activity. J Med Chem. 2020 May 8. https://doi.org/10.1021/acsmedchemlett.0c00119.
