M4K2149

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MedKoo CAT#: 593196

CAS#: unknown

Description: M4K2149 is a potent type I inhibitors of ALK2. It is an equipotent benzamide analogue.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-07. Prices are subject to change without notice.

is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 593196
Name: M4K2149
CAS#: unknown
Chemical Formula: C24H26N4O2
Exact Mass: 402.2056
Molecular Weight: 402.498
Elemental Analysis: C, 71.62; H, 6.51; N, 13.92; O, 7.95


Synonym: M4K2149; M4K-2149; M4K 2149

IUPAC/Chemical Name: 2-methoxy-4-(4-methyl-5-(4-(piperazin-1-yl)phenyl)pyridin-3-yl)benzamide

InChi Key: GFEAXKZXFORDDU-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H26N4O2/c1-16-21(17-3-6-19(7-4-17)28-11-9-26-10-12-28)14-27-15-22(16)18-5-8-20(24(25)29)23(13-18)30-2/h3-8,13-15,26H,9-12H2,1-2H3,(H2,25,29)

SMILES Code: COC1=C(C(N)=O)C=CC(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ensan D, Smil D, Zepeda-Velázquez CA, Panagopoulos D, Wong JF, Williams EP, Adamson R, Bullock AN, Kiyota T, Aman A, Roberts OG, Edwards AM, O'Meara JA, Isaac MB, Al-Awar R. Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 May 5. doi: 10.1021/acs.jmedchem.0c00395. [Epub ahead of print] PubMed PMID: 32369358.