WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 593195
CAS#: M4K2009 HCl
Description: M4K2009 is a potent type I inhibitors of ALK2. It is an analogue of the previously reported ALK2 inhibitor LDN-214117.
MedKoo Cat#: 593195
Name: M4K2009 HCl
CAS#: M4K2009 HCl
Chemical Formula: C25H30ClN3O3
Exact Mass: 419.2209
Molecular Weight: 455.983
Elemental Analysis: C, 65.85; H, 6.63; Cl, 7.77; N, 9.22; O, 10.53
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Synonym: M4K2009; M4K-2009; M4K 2009; M4K2009 HCl; M4K2009 Hydrochloride
IUPAC/Chemical Name: 1-(4-(4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine hydrochloride
InChi Key: KAZNWRAPVUYTOZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H29N3O3.ClH/c1-17-21(18-5-7-20(8-6-18)28-11-9-26-10-12-28)15-27-16-22(17)19-13-23(29-2)25(31-4)24(14-19)30-3;/h5-8,13-16,26H,9-12H2,1-4H3;1H
SMILES Code: COC1=CC(C2=CN=CC(C3=CC=C(C=C3)N4CCNCC4)=C2C)=CC(OC)=C1OC.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 455.983 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ensan D, Smil D, Zepeda-Velázquez CA, Panagopoulos D, Wong JF, Williams EP, Adamson R, Bullock AN, Kiyota T, Aman A, Roberts OG, Edwards AM, O'Meara JA, Isaac MB, Al-Awar R. Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 May 5. doi: 10.1021/acs.jmedchem.0c00395. [Epub ahead of print] PubMed PMID: 32369358.