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MedKoo CAT#: 555784
CAS#: 1172854-54-4 (HCl)
Description: NS-3-008 is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2). NS-3-008 can be used for chronic kidney disease. NS-3-008 inhibited the transcription of G0s2 with a half-maximal inhibitory concentration (IC50) of 2.25 μM. Moreover, treatment of wild-type 5/6Nx mice with NS-3-008 (5 mg/kg, P.O.) resulted in decreased levels of G0s2 and Ccl2 mRNA in the kidneys.
MedKoo Cat#: 555784
Name: NS-3-008 HCl
CAS#: 1172854-54-4 (HCl)
Chemical Formula: C14H24ClN3
Exact Mass:
Molecular Weight: 269.817
Elemental Analysis: C, 62.32; H, 8.97; Cl, 13.14; N, 15.57
Related CAS #: 1172854-54-4 (free base) 1172854-54-4 (HCl)
Synonym: NS-3-008 HCl; NS-3-008 hydrochloride; NS-3-008; NS 3-008; NS3-008; NS-3008; NS 3008; NS3008;
IUPAC/Chemical Name: 1-benzyl-3-hexylguanidine hydrochloride
InChi Key: UMIOAATZOCKZTH-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H23N3.ClH/c1-2-3-4-8-11-16-14(15)17-12-13-9-6-5-7-10-13;/h5-7,9-10H,2-4,8,11-12H2,1H3,(H3,15,16,17);1H
SMILES Code: N=C(NCC1=CC=CC=C1)NCCCCCC.[H]Cl
Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Chronic renal inflammation in CKD was ameliorated by clock mutation. G0s2 was important for the anti-inflammatory effects of clock mutation.
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(16)30463-7/fulltext