Kansuiphorin C
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MedKoo CAT#: 330029

CAS#: 133898-77-8

Description: Kansuiphorin C, also known as KPC is a natural product with a number of bioactivity. KPC could ameliorate malignant ascites by modulating gut microbiota mainly containing the increase of Lactobacillus and the decrease of Helicobacter and related carbohydrate and amino acid metabolism, providing a basis for their promising clinical usage.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 950 2 Weeks
10g USD 1750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-23. Prices are subject to change without notice.

Kansuiphorin C is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 330029
Name: Kansuiphorin C
CAS#: 133898-77-8
Chemical Formula: C29H34O6
Exact Mass: 478.2355
Molecular Weight: 478.585
Elemental Analysis: C, 72.78; H, 7.16; O, 20.06


Synonym: Kansuiphorin C

IUPAC/Chemical Name: (1aR,2R,5R,5aR,6S,8aS,9R,10aR)-6-(Acetyloxy)-5-(benzoyloxy)-1a,2,5,5a,6,9,10,10a-octahydro-5a-hydroxy-1,1,4,7,9-pentamethyl-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one

InChi Key: IDDLQFSLFADOOA-ISFUUBDKSA-N

InChi Code: InChI=1S/C29H34O6/c1-15-12-20-22-21(27(22,5)6)13-17(3)28(23(20)31)14-16(2)25(34-18(4)30)29(28,33)24(15)35-26(32)19-10-8-7-9-11-19/h7-12,14,17,20-22,24-25,33H,13H2,1-6H3/t17-,20-,21-,22+,24-,25+,28+,29+/m1/s1

SMILES Code: O=C1[C@@]2([H])[C@@]3([H])[C@@](C3(C)C)([H])C[C@@H](C)[C@@](C=C(C)[C@@H]4OC(C)=O)1[C@]4(O)[C@H](OC(C5=CC=CC=C5)=O)C(C)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Zhang Y, Lou JW, Kang A, Zhang Q, Zhou SK, Bao BH, Cao YD, Yao WF, Tang YP, Zhang L. Kansuiphorin C and Kansuinin A ameliorate malignant ascites by modulating gut microbiota and related metabolic functions. J Ethnopharmacol. 2020 Mar 1;249:112423. doi: 10.1016/j.jep.2019.112423. Epub 2019 Nov 22. PMID: 31765764.

2: Zhang Y, Lou JW, Zhang Q, Li ZL, Bao BH, Cao YD, Yao WF, Tang YP, Zhang L. Determination of kansuiphorin C and kansuinin A in rat feces using UFLC-MS/MS and its application in the comparative excretion study on normal and malignant ascites rats. J Pharm Biomed Anal. 2019 Jun 5;170:254-263. doi: 10.1016/j.jpba.2019.03.054. Epub 2019 Mar 26. PMID: 30947126.

3: Zhang L, Gao L, Li Z, Yan X, Yang Y, Tang Y, Cao Y, Ding A. Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1. Int J Mol Sci. 2012;13(9):11247-59. doi: 10.3390/ijms130911247. Epub 2012 Sep 10. PMID: 23109850; PMCID: PMC3472742.

4: Shu X, Yu L, Tang Y, Zhang L, Ding A, Luo D, Duan JA, Shen X. Bioassay-guided separation of the proinflammatory constituents from the roots of Euphorbia kansui. J Nat Med. 2010 Jan;64(1):98-103. doi: 10.1007/s11418-009-0366-0. Epub 2009 Oct 21. PMID: 19844773.

5: Wu TS, Lin YM, Haruna M, Pan DJ, Shingu T, Chen YP, Hsu HY, Nakano T, Lee KH. Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui. J Nat Prod. 1991 May-Jun;54(3):823-9. doi: 10.1021/np50075a011. PMID: 1955882.