WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 593185
Description: S7958 is a is a TAS2R8 antagonist. It was found to be non-mutagenic in vitro.
MedKoo Cat#: 593185
Chemical Formula: C21H23N5O4
Exact Mass: 409.175
Molecular Weight: 409.446
Elemental Analysis: Chemical Formula: C21H23N5O4 Exact Mass: 409.1750 Molecular Weight: 409.4460 Elemental Analysis: C, 61.60; H, 5.66; N, 17.10; O, 15.63
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Synonym: S7958; S-7958; S 7958
IUPAC/Chemical Name: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione
InChi Key: XQKWOHNWLKRKNA-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H23N5O4/c1-13-18(14(2)30-23-13)12-24-11-16(9-22-24)26-19(28)21(3,4)25(20(26)29)10-15-6-5-7-17(27)8-15/h5-9,11,27H,10,12H2,1-4H3
SMILES Code: O=C1N(C2=CN(CC3=C(C)ON=C3C)N=C2)C(C(C)(C)N1CC4=CC=CC(O)=C4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 409.446 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Fotsing JR, Darmohusodo V, Patron AP, Ching BW, Brady T, Arellano M, Chen Q, Davis TJ, Liu H, Servant G, Zhang L, Williams M, Saganich M, Ditschun T, Tachdjian C, Karanewsky DS. Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists. J Med Chem. 2020 Apr 24. doi: 10.1021/acs.jmedchem.0c00388. [Epub ahead of print] PubMed PMID: 32330040.
2: Karanewsky DS, Arthur AJ, Liu H, Chi B, Ida L, Markison S. Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imid azolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5 -dimethylimidazolidine-2,4-dione. Toxicol Rep. 2016 Feb 28;3:310-327. doi:10.1016/j.toxrep.2016.02.007. eCollection 2016. PubMed PMID: 28959552; PubMed Central PMCID: PMC5615838.