LML-134
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MedKoo CAT#: 555764

CAS#: 1542135-76-1

Description: LML134 is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 is potentially useful for the Clinical Treatment of Excessive Sleep Disorders.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 950 2 Weeks
200mg USD 1550 2 Weeks
500mg USD 2250 2 Weeks
1g USD 3250 2 Weeks
2g USD 5850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

LML-134 is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555764
Name: LML-134
CAS#: 1542135-76-1
Chemical Formula: C19H29N5O3
Exact Mass: 375.227
Molecular Weight: 375.473
Elemental Analysis: C, 60.78; H, 7.79; N, 18.65; O, 12.78


Synonym: LML-134; LML 134; LML134;

IUPAC/Chemical Name: 1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)piperidin-4-yl 4-cyclobutylpiperazine-1-carboxylate

InChi Key: BVUJMFFRMZRNAT-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H29N5O3/c1-21-18(25)6-5-17(20-21)23-9-7-16(8-10-23)27-19(26)24-13-11-22(12-14-24)15-3-2-4-15/h5-6,15-16H,2-4,7-14H2,1H3

SMILES Code: O=C(N1CCN(C2CCC2)CC1)OC3CCN(C(C=C4)=NN(C)C4=O)CC3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Histamine H3 receptor (H3R) inverse agonists that have been in clinical trials for the treatment of excessive sleep disorders, have been plagued with insomnia as a mechanism-based side effect


References

Troxler T, Feuerbach D, Zhang X, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019;14(13):1238–1247. doi:10.1002/cmdc.201900176