WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555764
Description: LML134 is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 is potentially useful for the Clinical Treatment of Excessive Sleep Disorders.
MedKoo Cat#: 555764
Chemical Formula: C19H29N5O3
Exact Mass: 375.227
Molecular Weight: 375.473
Elemental Analysis: C, 60.78; H, 7.79; N, 18.65; O, 12.78
Synonym: LML-134; LML 134; LML134;
IUPAC/Chemical Name: 1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)piperidin-4-yl 4-cyclobutylpiperazine-1-carboxylate
InChi Key: BVUJMFFRMZRNAT-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H29N5O3/c1-21-18(25)6-5-17(20-21)23-9-7-16(8-10-23)27-19(26)24-13-11-22(12-14-24)15-3-2-4-15/h5-6,15-16H,2-4,7-14H2,1H3
SMILES Code: O=C(N1CCN(C2CCC2)CC1)OC3CCN(C(C=C4)=NN(C)C4=O)CC3
Histamine H3 receptor (H3R) inverse agonists that have been in clinical trials for the treatment of excessive sleep disorders, have been plagued with insomnia as a mechanism-based side effect
Troxler T, Feuerbach D, Zhang X, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019;14(13):1238–1247. doi:10.1002/cmdc.201900176