WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555758
CAS#: 688348-33-6
Description: CAY10465 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor agonist, with a Ki of 0.2 nM. CAY10465 is inactive as a ligand for the estrogen receptor even at 100 µM.
MedKoo Cat#: 555758
Name: CAY10465
CAS#: 688348-33-6
Chemical Formula: C15H9Cl2F3
Exact Mass: 316.0033
Molecular Weight: 317.1322
Elemental Analysis: C, 56.81; H, 2.86; Cl, 22.36; F, 17.97
Synonym: CAY10465; CAY-10465; CAY 10465;
IUPAC/Chemical Name: 1,3-dichloro-5-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-benzene
InChi Key: ISPYNXGXZRLLHM-OWOJBTEDSA-N
InChi Code: InChI=1S/C15H9Cl2F3/c16-13-7-11(8-14(17)9-13)2-1-10-3-5-12(6-4-10)15(18,19)20/h1-9H/b2-1+
SMILES Code: FC(C1=CC=C(/C=C/C2=CC(Cl)=CC(Cl)=C2)C=C1)(F)F
1. Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 43, 309-334 (2003).
2. de Medina, P., Casper, R., Savouret, J.F., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. Journal of Medicinal Chemistry 48, 287-291 (2005).
3. Naem E, Alcalde R, Gladysz M, et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012;91(1-2):64–69. doi:10.1016/j.lfs.2012.06.002
