WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555752
Description: ML-329 is an inhibitor of the microphthalmia-associated transcription factor (MITF) pathway with an IC50 value of 1.2 μM for promoter activity of the MITF target gene TRPM-1. ML329 showed specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduced the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.
MedKoo Cat#: 555752
Chemical Formula: C16H12N2O4S
Exact Mass: 328.0518
Molecular Weight: 328.342
Elemental Analysis: C, 58.53; H, 3.68; N, 8.53; O, 19.49; S, 9.76
Synonym: ML329; ML 329; ML-329; CID 12387471; CID12387471; CID-12387471;
IUPAC/Chemical Name: 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide
InChi Key: CSYFFQVEQXEIAB-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H12N2O4S/c17-23(21,22)11-7-5-10(6-8-11)18-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9,18H,(H2,17,21,22)
SMILES Code: O=S(C1=CC=C(NC(C2=O)=CC(C3=C2C=CC=C3)=O)C=C1)(N)=O
Micropthalmia-associated transcription factor (MITF) is a lineage restricted basic helix-loop-helix leucine zipper transcription factor that is essential for melanocyte development, function and survival. 15% of human melanomas have MITF gene amplification. In addition, a vast majority of melanomas are dependent upon MITF for survival.
Faloon PW, Bennion M, Weiner WS, et al. A Small Molecule Inhibitor of the MITF Molecular Pathway. In: Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010.