VUF10460
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555751

CAS#: 1028327-66-3

Description: VUF10460 is a histamine H4 receptor agonist.


Chemical Structure

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VUF10460
CAS# 1028327-66-3

Theoretical Analysis

MedKoo Cat#: 555751
Name: VUF10460
CAS#: 1028327-66-3
Chemical Formula: C15H19N5
Exact Mass: 269.16
Molecular Weight: 269.352
Elemental Analysis: C, 66.89; H, 7.11; N, 26.00

Price and Availability

Size Price Availability Quantity
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1550 2 Weeks
1g USD 2850 2 Weeks
2g USD 5150 2 Weeks
Bulk inquiry

Synonym: VUF10460; VUF-10460; VUF 10460;

IUPAC/Chemical Name: 4-(4-Methyl-1-piperazinyl)-6-phenyl-2-Pyrimidinamine

InChi Key: NIJGWJIOMPHDBP-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H19N5/c1-19-7-9-20(10-8-19)14-11-13(17-15(16)18-14)12-5-3-2-4-6-12/h2-6,11H,7-10H2,1H3,(H2,16,17,18)

SMILES Code: NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 269.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Adami M, Pozzoli C, Menozzi A, Bertini S, Passeri B, Cantoni AM, Smits R, de Esch I, Leurs R, Coruzzi G. Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration. Pharmacology. 2012;89(5-6):287-94. doi: 10.1159/000337736. PMID: 22538763.


2: Coruzzi G, Adami M, Pozzoli C, de Esch IJ, Smits R, Leurs R. Selective histamine H₃ and H₄ receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur J Pharmacol. 2011 Nov 1;669(1-3):121-7. doi: 10.1016/j.ejphar.2011.07.038. Epub 2011 Aug 5. PMID: 21839070.