CL2A-SN38 DCA
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MedKoo CAT#: 408080

CAS#: 1279680-68-0 (free base)

Description: CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC). CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .


Price and Availability

Size Price Shipping out time Quantity
50mg USD 1450 2 Weeks
100mg USD 2250 2 Weeks
200mg USD 3450 2 Weeks
500mg USD 6050 2 Weeks
1g USD 9650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-28. Prices are subject to change without notice.

CL2A-SN38 DCA (CL2A-SN38 dichloroacetic acid salt) is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 408080
Name: CL2A-SN38 DCA
CAS#: 1279680-68-0 (free base)
Chemical Formula: C77H101Cl4N11O26
Exact Mass: 1479.681
Molecular Weight: 1738.506
Elemental Analysis: C, 53.20; H, 5.86; Cl, 8.16; N, 8.86; O, 23.93


Related CAS #: 1279680-68-0 (free base)    

Synonym: CL2A-SN-38; CL2A-SN 38; CL2A-SN38; CL2ASN-38; CL2A SN 38; CL2ASN38; CL2A-SN38 DCA salt; CL2A-SN38 dichloroacetic acid.

IUPAC/Chemical Name: 4-((S)-2-(4-aminobutyl)-35-(4-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexane-1-carboxamido)methyl)-1H-1,2,3-triazol-1-yl)-4,8-dioxo-6,12,15,18,21,24,27,30,33-nonaoxa-3,9-diazapentatriacontanamido)benzyl ((S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl) carbonate bis(2,2-dichloroacetate)

InChi Key: WWSNNYDLXHTRLZ-JGQYWRMXSA-N

InChi Code: InChI=1S/C73H97N11O22.2C2H2Cl2O2/c1-3-55-56-39-54(85)16-17-60(56)79-67-57(55)44-83-62(67)40-59-58(70(83)92)46-104-71(93)73(59,4-2)106-72(94)105-45-50-10-14-52(15-11-50)77-69(91)61(7-5-6-20-74)78-64(87)48-103-47-63(86)75-21-23-95-25-27-97-29-31-99-33-35-101-37-38-102-36-34-100-32-30-98-28-26-96-24-22-82-43-53(80-81-82)41-76-68(90)51-12-8-49(9-13-51)42-84-65(88)18-19-66(84)89;2*3-1(4)2(5)6/h10-11,14-19,39-40,43,49,51,61,85H,3-9,12-13,20-38,41-42,44-48,74H2,1-2H3,(H,75,86)(H,76,90)(H,77,91)(H,78,87);2*1H,(H,5,6)/t49?,51?,61-,73-;;/m0../s1

SMILES Code: O=C(O[C@@]1(CC)C2=C(C(N3CC4=C(C5=CC(O)=CC=C5N=C4C3=C2)CC)=O)COC1=O)OCC6=CC=C(C=C6)NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CC8)CN9C(C=CC9=O)=O)=O)=C7)=O)=O)CCCCN)=O.O=C(O)C(Cl)Cl.O=C(O)C(Cl)Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

Cardillo TM, Govindan SV, Sharkey RM, Trisal P, Goldenberg DM. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011;17(10):3157–3169. doi:10.1158/1078-0432.CCR-10-2939