CL2A-SN38 DCA
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MedKoo CAT#: 408080

CAS#: 1279680-68-0 (free base)

Description: CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC). CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .


Price and Availability

Size Price Shipping out time Quantity
1mg USD 90 Same day
5mg USD 350 Same day
10mg USD 550 Same day
25mg USD 950 Same day
50mg USD 1550 Same day
100mg USD 2250 Same day
200mg USD 3850 Same day
500mg USD 6950 Same day
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Pricing updated 2021-01-26. Prices are subject to change without notice.

CL2A-SN38 DCA (CL2A-SN38 dichloroacetic acid salt) is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 408080
Name: CL2A-SN38 DCA
CAS#: 1279680-68-0 (free base)
Chemical Formula: C77H101Cl4N11O26
Exact Mass: 1479.681
Molecular Weight: 1738.506
Elemental Analysis: C, 53.20; H, 5.86; Cl, 8.16; N, 8.86; O, 23.93


Related CAS #: 1279680-68-0 (free base)    

Synonym: CL2A-SN-38; CL2A-SN 38; CL2A-SN38; CL2ASN-38; CL2A SN 38; CL2ASN38; CL2A-SN38 DCA salt; CL2A-SN38 dichloroacetic acid.

IUPAC/Chemical Name: 4-((S)-2-(4-aminobutyl)-35-(4-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexane-1-carboxamido)methyl)-1H-1,2,3-triazol-1-yl)-4,8-dioxo-6,12,15,18,21,24,27,30,33-nonaoxa-3,9-diazapentatriacontanamido)benzyl ((S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl) carbonate bis(2,2-dichloroacetate)

InChi Key: WWSNNYDLXHTRLZ-JGQYWRMXSA-N

InChi Code: InChI=1S/C73H97N11O22.2C2H2Cl2O2/c1-3-55-56-39-54(85)16-17-60(56)79-67-57(55)44-83-62(67)40-59-58(70(83)92)46-104-71(93)73(59,4-2)106-72(94)105-45-50-10-14-52(15-11-50)77-69(91)61(7-5-6-20-74)78-64(87)48-103-47-63(86)75-21-23-95-25-27-97-29-31-99-33-35-101-37-38-102-36-34-100-32-30-98-28-26-96-24-22-82-43-53(80-81-82)41-76-68(90)51-12-8-49(9-13-51)42-84-65(88)18-19-66(84)89;2*3-1(4)2(5)6/h10-11,14-19,39-40,43,49,51,61,85H,3-9,12-13,20-38,41-42,44-48,74H2,1-2H3,(H,75,86)(H,76,90)(H,77,91)(H,78,87);2*1H,(H,5,6)/t49?,51?,61-,73-;;/m0../s1

SMILES Code: O=C(O[C@@]1(CC)C2=C(C(N3CC4=C(C5=CC(O)=CC=C5N=C4C3=C2)CC)=O)COC1=O)OCC6=CC=C(C=C6)NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC(CNC(C8CCC(CC8)CN9C(C=CC9=O)=O)=O)=C7)=O)=O)CCCCN)=O.O=C(O)C(Cl)Cl.O=C(O)C(Cl)Cl


Technical Data

Appearance:
Solid powder

Purity:
>95% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

Cardillo TM, Govindan SV, Sharkey RM, Trisal P, Goldenberg DM. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011;17(10):3157–3169. doi:10.1158/1078-0432.CCR-10-2939