WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555733
CAS#: 1839150-63-8 (bromide)
Description: EB-3D is a novel potent and selective choline kinase ChoKα inhibitor. EB-3D Induces Deregulation of the AMPK-mTOR Pathway and Apoptosis in Leukemia T-cells. EB-3D induces senescence in breast cancer cell lines through the activation of the metabolic sensor AMPK and the subsequent dephosphorylation of mTORC1 downstream targets, such as p70S6K, S6 ribosomal protein, and 4E-BP1. Moreover, EB-3D strongly synergizes with drugs commonly used for breast cancer treatment.
MedKoo Cat#: 555733
Name: EB-3D
CAS#: 1839150-63-8 (bromide)
Chemical Formula: C30H36Br2N4O2
Exact Mass:
Molecular Weight: 644.452
Elemental Analysis: C, 55.91; H, 5.63; Br, 24.80; N, 8.69; O, 4.97
Related CAS #: 1839150-62-7 (cation) 1839150-63-8 (bromide)
Synonym: EB-3D; EB 3D; EB3D;
IUPAC/Chemical Name: 1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridinium) bromide
InChi Key: SCXVGPSPZQBBDM-UHFFFAOYSA-L
InChi Code: InChI=1S/C30H36N4O2.2BrH/c1-31(2)27-13-17-33(18-14-27)23-25-5-9-29(10-6-25)35-21-22-36-30-11-7-26(8-12-30)24-34-19-15-28(16-20-34)32(3)4;;/h5-20H,21-24H2,1-4H3;2*1H/q+2;;/p-2
SMILES Code: CN(C1=CC=[N+](CC2=CC=C(OCCOC3=CC=C(C[N+]4=CC=C(N(C)C)C=C4)C=C3)C=C2)C=C1)C.[Br-].[Br-]
Choline kinase alpha 1 (ChoKα1) has recently become an interesting therapeutic target since its overexpression has been associated to tumorigenesis in many cancers.