WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585431
Description: Wy 27569 is is a combined calcium channel blocker and thromboxane synthetase inhibitor.
MedKoo Cat#: 585431
Name: Wy 27569
Chemical Formula: C21H22N4O6
Exact Mass: 426.1539
Molecular Weight: 426.429
Elemental Analysis: C, 59.15; H, 5.20; N, 13.14; O, 22.51
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Wy 27569; Wy27569; Wy-27569
IUPAC/Chemical Name: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-(1H-imidazol-1-ylmethyl)-6-methyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester
InChi Key: BFLKGKGRZKABHQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H22N4O6/c1-4-31-21(27)19-16(11-24-9-8-22-12-24)23-13(2)17(20(26)30-3)18(19)14-6-5-7-15(10-14)25(28)29/h5-10,12,18,23H,4,11H2,1-3H3
SMILES Code: O=C(C1=C(CN2C=CN=C2)NC(C)=C(C(OC)=O)C1C3=CC=CC([N+]([O-])=O)=C3)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 426.429 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Archibald JL, Bradley G, Opalko A, Ward TJ, White JC, Ennis C, Shepperson NB. Design of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl-substituted dihydropyridines. J Med Chem. 1990 Feb;33(2):646-52. PubMed PMID: 2299629.
2: Ennis C, Granger SE, Middlefell VC, Philpot ME, Shepperson NB. Pharmacologic effects of Wy 27569: a combined calcium channel blocker and thromboxane synthetase inhibitor. J Cardiovasc Pharmacol. 1989 Apr;13(4):511-9. PubMed PMID: 2470986.