WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585429
Description: Wy 27127 is an alpha 2-adrenoceptors antagonist that has estimated potency based on ability to block clonidine-induced inhibition of electrically-evoked contractions of the rat isolated vas deferens.
MedKoo Cat#: 585429
Name: Wy 27127
Chemical Formula: C17H27N3O4S2
Exact Mass: 401.1443
Molecular Weight: 401.54
Elemental Analysis: C, 50.85; H, 6.78; N, 10.46; O, 15.94; S, 15.97
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Wy 27127; Wy27127; Wy-27127
IUPAC/Chemical Name: N-[2-[[(2R,11bS)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-methylsulfonylamino]ethyl]methanesulfonamide
InChi Key: VSQCTWPNMPWYSD-WBVHZDCISA-N
InChi Code: InChI=1S/C17H27N3O4S2/c1-25(21,22)18-9-12-20(26(2,23)24)15-8-11-19-10-7-14-5-3-4-6-16(14)17(19)13-15/h3-6,15,17-18H,7-13H2,1-2H3/t15-,17+/m1/s1
SMILES Code: CS(=O)(NCCN([C@@H]1CCN2CCC3=CC=CC=C3[C@]2([H])C1)S(=O)(C)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 401.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Bill SJ, Boniface A, Haroun F, McAdams RP, Lattimer N, Rhodes KF. Some pharmacological properties of Wy 27127 a more selective alpha 2:alpha 1-adrenoceptor antagonist than idazoxan in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):418-22. PubMed PMID: 2881217.
2: Blaxall HS, Murphy TJ, Baker JC, Ray C, Bylund DB. Characterization of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line. J Pharmacol Exp Ther. 1991 Oct;259(1):323-9. PubMed PMID: 1656026.
3: Loomis CW, Arunachalam KD. Intrathecal St-587: effects on nociceptive reflexes and blood pressure in the rat. J Pharmacol Exp Ther. 1992 Nov;263(2):428-35. PubMed PMID: 1331398.
4: Wy 27127: A Peripherally Acting Alpha-2 Adrenoceptor Antagonist: HARTLEY JE and FLETCHER A. Wyeth Research (UK) Ltd., Huntercombe Lane South, Taplow, Maidenhead, Berks. SL6 0PH. J Psychopharmacol. 1992 Jan;6(1):106. doi: 10.1177/026988119200600131. PubMed PMID: 22291259.
5: Rhodes KF, Waterfall JF. The effects of some alpha-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine. Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):261-8. PubMed PMID: 2884574.