Wy 26392

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585428

CAS#: 82059-29-8

Description: Wy 26392 is an alpha 2 adrenoceptors antagonist that increase central sympathetic tone and blood pressure in low doses.

Chemical Structure

Wy 26392
CAS# 82059-29-8

Theoretical Analysis

MedKoo Cat#: 585428
Name: Wy 26392
CAS#: 82059-29-8
Chemical Formula: C17H27ClN2O2S
Exact Mass: 358.1482
Molecular Weight: 358.925
Elemental Analysis: C, 56.89; H, 7.58; Cl, 9.88; N, 7.80; O, 8.91; S, 8.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Wy 26392; Wy26392; Wy-26392

IUPAC/Chemical Name: N-[(11bR)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-N-methylpropane-1-sulfonamide;hydrochloride


InChi Code: InChI=1S/C17H26N2O2S.ClH/c1-3-12-22(20,21)18(2)15-9-11-19-10-8-14-6-4-5-7-16(14)17(19)13-15;/h4-7,15,17H,3,8-13H2,1-2H3;1H/t15?,17-;/m1./s1

SMILES Code: CCCS(=O)(N(C1CCN2CCC3=CC=CC=C3[C@@]2([H])C1)C)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 358.925 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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10: Gower AJ, Tricklebank MD. Alpha 2-adrenoceptor antagonist activity may account for the effects of buspirone in an anticonflict test in the rat. Eur J Pharmacol. 1988 Oct 11;155(1-2):129-37. PubMed PMID: 2907485.

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13: Oyekan AO, Botting JH. Adrenaline inhibits adenosine diphosphate induced intravascular aggregation of rat platelets through stimulation of alpha 2 adrenoceptors. Cardiovasc Res. 1991 May;25(5):431-7. PubMed PMID: 1677313.

14: McAdams RP, Waterfall JF. The effect of age on the sensitivity of pre- and postsynaptic alpha-adrenoceptors to agonists and antagonists in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):430-5. Erratum in: Naunyn Schmiedebergs Arch Pharmacol 1987 Apr;335(4):480. PubMed PMID: 2881219.

15: Lattimer N, McAdams RP, Rhodes KF, Sharma S, Turner SJ, Waterfall JF. Alpha 2-adrenoceptor antagonism and other pharmacological antagonist properties of some substituted benzoquinolizines and yohimbine in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1984 Oct;327(4):312-8. PubMed PMID: 6151116.

16: Paciorek PM, Shepperson NB. alpha 1-Adrenoceptor agonist activity of alpha 2-adrenoceptor antagonists in the pithed rat preparation. Br J Pharmacol. 1983 May;79(1):12-4. PubMed PMID: 6135473; PubMed Central PMCID: PMC2044847.

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19: Paciorek PM, Shepperson NB. The alpha 2-adrenoceptor selectivities and haemodynamic effects of WY26392 and yohimbine in the anaesthetised dog. Eur J Pharmacol. 1985 Apr 2;110(2):191-201. PubMed PMID: 2859215.