NG 012
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MedKoo CAT#: 574240

CAS#: 141731-76-2

Description: NG 012 is a fungal metabolite with fungicidal and nerve growth factor-potentiating properties. NG 012 increases the efficacy of the antifungal miconazole against C. albicans. It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner.


Price and Availability

Size Price Shipping out time Quantity
1mg USD 275 2 Weeks
5mg USD 850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-22. Prices are subject to change without notice.

NG 012, purity > 95%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 574240
Name: NG 012
CAS#: 141731-76-2
Chemical Formula: C32H38O15
Exact Mass: 662.2211
Molecular Weight: 662.64
Elemental Analysis: C, 58.00; H, 5.78; O, 36.22


Synonym: BK223-A, NG 012, NG012, NG-012

IUPAC/Chemical Name: 7R,8,11S,12,15R,16,23R,24,27R,28-decahydro-2,4,18,20-tetrahydroxy-11-(hydroxymethyl)-7,15,23,27-tetramethyl-5H,9H,13H,21H,25H-dibenzo[k,u][1,5,9,15,19]pentaoxacyclotetracosin-5,9,13,21,25-pentone

InChi Key: QFILNQIVBJLREP-RZOYPLJHSA-N

InChi Code: InChI=1S/C32H38O15/c1-15-5-19-9-21(34)11-24(36)29(19)32(42)46-18(4)8-27(39)47-23(14-33)13-28(40)44-16(2)6-20-10-22(35)12-25(37)30(20)31(41)45-17(3)7-26(38)43-15/h9-12,15-18,23,33-37H,5-8,13-14H2,1-4H3/t15-,16-,17-,18-,23+/m1/s1

SMILES Code: OC(C=C1O)=CC(C[C@@H](C)OC(C[C@@H](C)OC(C2=C(O)C=C(O)C=C2C[C@@H](C)OC(C[C@@H](CO)OC(C[C@@H](C)O3)=O)=O)=O)=O)=C1C3=O


Technical Data

Appearance:
Solid powder

Purity:
>95% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1. Breinholt, J., Jensen, G.W., and Nielsen, R.I. Antifungal macrocyclic polylactones from Penicillium verruculosum. J. Antibiot. (Tokyo) 46(7), 1101-1108 (1993).

2. Ito, M., Maruhashi, M., Sakai, N., et al. NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico-chemical and biological properties. J. Antibiot. (Tokyo) 45(10), 1559-1565 (1992).

3. Arai, M., Tomada, H., Okuda, T., et al. Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromyces flavus FKI-0076. J. Antibiot. (Tokyo) 55(2), 172-180 (2002).