DCZ0415
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 533447

CAS#: 2242470-43-3

Description: DCZ0415 is a novel inhibitor of TRIP13, suppressing multiple myeloma progression.


Chemical Structure

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DCZ0415
CAS# 2242470-43-3

Theoretical Analysis

MedKoo Cat#: 533447
Name: DCZ0415
CAS#: 2242470-43-3
Chemical Formula: C23H20N2O2
Exact Mass: 356.15
Molecular Weight: 356.425
Elemental Analysis: C, 77.51; H, 5.66; N, 7.86; O, 8.98

Price and Availability

Size Price Availability Quantity
5mg USD 150 Ready to ship
10mg USD 250 Ready to ship
25mg USD 450 Ready to ship
50mg USD 750 Ready to ship
100mg USD 1250 Ready to ship
200mg USD 1950 Ready to ship
500mg USD 3250 Ready to ship
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Synonym: DCZ0415; DCZ-0415; DCZ 0415;

IUPAC/Chemical Name: 2-(4-(Pyridin-4-ylmethyl)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione

InChi Key: LOXMLWHUIONWMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20N2O2/c26-22-20-16-5-6-17(19-12-18(16)19)21(20)23(27)25(22)15-3-1-13(2-4-15)11-14-7-9-24-10-8-14/h1-10,16-21H,11-12H2

SMILES Code: O=C1N(C2=CC=C(CC3=CC=NC=C3)C=C2)C(C4C5C(C6)C6C(C=C5)C14)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity.
In vitro activity: To evaluate the inhibitory effect of DCZ0415, multiple myeloma cells were treated with DCZ0415 for 72 hours and cell viability was assessed. Data showed that DCZ0415 induced a significant dose-dependent decrease in viability (Fig. 3A). Reference: Cancer Res. 2020 Feb 1;80(3):536-548. https://cancerres.aacrjournals.org/content/80/3/536.long
In vivo activity: To investigate the therapeutic potential of DCZ0415 in vivo, an multiple myeloma mouse xenograft model was employed. The administration of DCZ0415 significantly reduced the growth of multiple myeloma cells-induced tumors in immunodeficient mice compared with control mice (Fig. 7A). Reference: Cancer Res. 2020 Feb 1;80(3):536-548. https://cancerres.aacrjournals.org/content/80/3/536.long

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 62.5 175.35

Preparing Stock Solutions

The following data is based on the product molecular weight 356.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Wang Y, Huang J, Li B, Xue H, Tricot G, Hu L, Xu Z, Sun X, Chang S, Gao L, Tao Y, Xu H, Xie Y, Xiao W, Yu D, Kong Y, Chen G, Sun X, Lian F, Zhang N, Wu X, Mao Z, Zhan F, Zhu W, Shi J. A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression. Cancer Res. 2020 Feb 1;80(3):536-548. doi: 10.1158/0008-5472.CAN-18-3987. Epub 2019 Nov 15. PMID: 31732653.
In vitro protocol: 1. Wang Y, Huang J, Li B, Xue H, Tricot G, Hu L, Xu Z, Sun X, Chang S, Gao L, Tao Y, Xu H, Xie Y, Xiao W, Yu D, Kong Y, Chen G, Sun X, Lian F, Zhang N, Wu X, Mao Z, Zhan F, Zhu W, Shi J. A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression. Cancer Res. 2020 Feb 1;80(3):536-548. doi: 10.1158/0008-5472.CAN-18-3987. Epub 2019 Nov 15. PMID: 31732653.
In vivo protocol: 1. Wang Y, Huang J, Li B, Xue H, Tricot G, Hu L, Xu Z, Sun X, Chang S, Gao L, Tao Y, Xu H, Xie Y, Xiao W, Yu D, Kong Y, Chen G, Sun X, Lian F, Zhang N, Wu X, Mao Z, Zhan F, Zhu W, Shi J. A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression. Cancer Res. 2020 Feb 1;80(3):536-548. doi: 10.1158/0008-5472.CAN-18-3987. Epub 2019 Nov 15. PMID: 31732653.

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