AGX51
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 533417

CAS#: 330834-54-3

Description: AGX51 is a first-in-class pan-Id antagonist, inhibiting pathologic ocular neovascularization and the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduced viability.


Chemical Structure

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AGX51
CAS# 330834-54-3

Theoretical Analysis

MedKoo Cat#: 533417
Name: AGX51
CAS#: 330834-54-3
Chemical Formula: C28H31NO3
Exact Mass: 429.23
Molecular Weight: 429.560
Elemental Analysis: C, 78.29; H, 7.27; N, 3.26; O, 11.17

Price and Availability

Size Price Availability Quantity
50mg USD 950 2 Weeks
100mg USD 1650 2 Weeks
200mg USD 2950 2 Weeks
500mg USD 3950 2 Weeks
1g USD 4950 2 Weeks
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Synonym: AGX51; AGX-51; AGX 51

IUPAC/Chemical Name: N-Benzyl-N-(3-(2,3-dihydrobenzofuran-6-yl)-3-(2-methoxyphenyl)propyl)propionamide

InChi Key: RPUIBPORFRUAAZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H31NO3/c1-3-28(30)29(20-21-9-5-4-6-10-21)17-15-24(25-11-7-8-12-26(25)31-2)23-14-13-22-16-18-32-27(22)19-23/h4-14,19,24H,3,15-18,20H2,1-2H3

SMILES Code: CCC(N(CC1=CC=CC=C1)CCC(C2=CC=C3CCOC3=C2)C4=CC=CC=C4OC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wojnarowicz PM, Lima E Silva R, Ohnaka M, Lee SB, Chin Y, Kulukian A, Chang SH, Desai B, Garcia Escolano M, Shah R, Garcia-Cao M, Xu S, Kadam R, Goldgur Y, Miller MA, Ouerfelli O, Yang G, Arakawa T, Albanese SK, Garland WA, Stoller G, Chaudhary J, Norton L, Soni RK, Philip J, Hendrickson RC, Iavarone A, Dannenberg AJ, Chodera JD, Pavletich N, Lasorella A, Campochiaro PA, Benezra R. A Small- Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7. doi: 10.1016/j.celrep.2019.08.073. PMID: 31577956; PMCID: PMC6896334.


2: Wojnarowicz PM, Escolano MG, Huang YH, Desai B, Chin Y, Shah R, Xu S, Yadav S, Yaklichkin S, Ouerfelli O, Soni RK, Philip J, Montrose DC, Healey JH, Rajasekhar VK, Garland WA, Ratiu J, Zhuang Y, Norton L, Rosen N, Hendrickson RC, Zhou XK, Iavarone A, Massague J, Dannenberg AJ, Lasorella A, Benezra R. Anti- tumor effects of an ID antagonist with no observed acquired resistance. NPJ Breast Cancer. 2021 May 24;7(1):58. doi: 10.1038/s41523-021-00266-0. PMID: 34031428; PMCID: PMC8144414.


3: Zhong G, Wang Y, Wang Q, Wu M, Liu Y, Sun S, Li Z, Hao J, Dou P, Lin B. Discovery of novel ID2 antagonists from pharmacophore-based virtual screening as potential therapeutics for glioma. Bioorg Med Chem. 2021 Nov 1;49:116427. doi: 10.1016/j.bmc.2021.116427. Epub 2021 Sep 25. PMID: 34600240.