WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574231
Description: NG-25 HCl hydrate is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner. It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer.
MedKoo Cat#: 574231
Name: NG-25 HCl hydrate
Chemical Formula: C29H35Cl3F3N5O3
Exact Mass: 663.1758
Molecular Weight: 664.98
Elemental Analysis: C, 52.38; H, 5.31; Cl, 15.99; F, 8.57; N, 10.53; O, 7.22
Synonym: NG-25 HCl hydrate, NG 25 HCl hydrate, NG-25 Hydrochloride hydrate
IUPAC/Chemical Name: N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide, trihydrochloride, hydrate
InChi Key: MTCWJLFLTFRXLX-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H30F3N5O2.3ClH.H2O/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27;;;;/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38);3*1H;1H2
SMILES Code: CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(OC4=CC=NC5=C4C=CN5)=C(C)C=C3)=O)C=C2)CC1.Cl.Cl.Cl.O
1. Tan, L., Nomanbhoy, T., Gurbani, D., et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J. Med. Chem. 58(1), 183-196 (2015).
2. Pauls, E., Shpiro, N., Peggie, M., et al. Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells. J. Biol. Chem. 287(23), 19216-19228 (2012).
3. Ma, Q., Gu, L., Liao, S., et al. NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivo. Apoptosis 24(1-2), 83-94 (2019).